Hurd T C, Dasmahapatra K S, Rush B F, Machiedo G W
Surgical Service, Veterans Administration Medical Center, East Orange, NJ.
Arch Surg. 1988 Feb;123(2):217-20. doi: 10.1001/archsurg.1988.01400260101012.
Red blood cell (RBC) "deformability" is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 +/- 0.12) compared with patients without sepsis (1.62 +/- 0.13) and normal control volunteers (1.51 +/- 0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37 +/- 0.06) compared with that of sham-operated rats (0.76 +/- 0.12), as well as in endotoxemic rats (0.38 +/- 0.4) compared with control rats (0.82 +/- 0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.
红细胞（RBC）“可变形性”对于维持正常微循环至关重要。为了确定人类或小鼠脓毒症中红细胞可变形性是否受到影响，在一项人体研究和一个小鼠模型中测定了可变形性指数。与非脓毒症患者（1.62±0.13）和正常对照志愿者（1.51±0.17）相比，脓毒症患者术后可变形性降低（0.49±0.12）。与假手术大鼠（0.76±0.12）相比，接受盲肠结扎和穿刺的大鼠可变形性降低（0.37±0.06），与对照大鼠（0.82±0.11）相比，内毒素血症大鼠的可变形性也降低（0.38±0.4）。这些数据表明，人类和小鼠脓毒症中红细胞可变形性均降低。这种效应可能是人类脓毒症中氧利用紊乱的一个重要因素，纠正这一效应可能导致更好的组织氧合和维持器官功能。
