Mathers W D, Jester J V, Lemp M A
Department of Ophthalmology, University of Arizona Health Science Center, Tucson.
Arch Ophthalmol. 1988 Feb;106(2):210-1. doi: 10.1001/archopht.1988.01060130220030.
To evaluate the reinnervation of corneal grafts, we studied 91 eyes of 79 patients for the return of sensitivity one month to ten years following penetrating keratoplasty for various corneal disorders including keratoconus, Fuchs' dystrophy, herpes simplex keratitis, aphakic and pseudophakic bullous keratopathy, glaucoma, trauma, and interstitial keratitis. Using the Cochet-Bonnet esthesiometer, a sensation was recorded in the center of the graft no earlier than 18 months. We found a progressive return of sensitivity from the periphery toward the center of the graft. Regression analysis indicated a rate of return of sensitivity that averaged 0.029 mm/mo for each diagnostic category except herpes simplex keratitis. The slope of the return of sensitivity in the group with herpes simplex keratitis was essentially flat, showing no central progression. None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin.
为了评估角膜移植片的神经再支配情况，我们研究了79例患者的91只眼睛，这些患者因圆锥角膜、富克斯营养不良、单纯疱疹性角膜炎、无晶状体和人工晶状体大泡性角膜病变、青光眼、外伤以及间质性角膜炎等各种角膜疾病接受穿透性角膜移植术后1个月至10年的感觉恢复情况。使用科谢 - 博内触觉计，在移植片中央最早在18个月时才记录到感觉。我们发现感觉从移植片周边向中央逐渐恢复。回归分析表明，除单纯疱疹性角膜炎外，每个诊断类别的感觉恢复率平均为每月0.029毫米。单纯疱疹性角膜炎组感觉恢复的斜率基本呈水平，未显示向中央进展。8例单纯疱疹性角膜炎患者中，没有一例在距伤口边缘超过0.5毫米处记录到感觉。
