Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Department of Medicine, Mount Sinai Beth Israel, New York, New York, USA.
Obesity (Silver Spring). 2020 Sep;28(9):1671-1677. doi: 10.1002/oby.22903. Epub 2020 Aug 9.
This study aimed to elucidate medical weight-loss outcomes in patients unexposed or exposed to psychotropic medication(s).
This retrospective cohort study evaluated weight-loss outcomes of completers treated at an academic weight-management center between April 1, 2014, and April 1, 2016. Patients were classified as either unexposed (not prescribed psychotropic medication) or exposed (prescribed psychotropic medication) based on use of antidepressants, mood stabilizers, or antipsychotics during the study.
Of 1,932 patients seen during the study period, 885 were eligible for inclusion, of whom 619 (70.0%) were unexposed and 266 (30.0%) were exposed to psychotropic medications. In the unexposed and exposed groups, the mean age, sex distribution, proportion with type 2 diabetes, initial BMI, and number of weight-loss medications prescribed were similar. At 12 months, the unexposed group lost 1.6% more weight on average than the exposed group (9.1% [SD 7.6%] vs. 7.5% [SD 8.1%], respectively; P = 0.02); 71.0% and 41.2% of the unexposed group achieved ≥ 5% and ≥ 10% weight loss at 12 months, respectively, compared with 63.1% and 31.8% in the exposed group at 12 months (P = 0.04 at 5%; P = 0.02 at 10%).
Exposure to psychotropic medications was associated with diminished weight loss in patients with medically managed overweight and obesity.
本研究旨在阐明未使用或使用精神药物治疗的患者的医学减重结果。
本回顾性队列研究评估了 2014 年 4 月 1 日至 2016 年 4 月 1 日期间在学术体重管理中心接受治疗的患者的减重结果。根据研究期间是否使用抗抑郁药、心境稳定剂或抗精神病药，将患者分为未暴露（未开具精神药物）或暴露（开具精神药物）组。
在研究期间就诊的 1932 名患者中，有 885 名符合纳入标准，其中 619 名（70.0%）未暴露于精神药物，266 名（30.0%）暴露于精神药物。在未暴露组和暴露组中，平均年龄、性别分布、2 型糖尿病比例、初始 BMI 和开具的减重药物数量相似。在 12 个月时，未暴露组的体重平均减轻了 1.6%，而暴露组则减轻了 7.5%（分别为 9.1%[标准差 7.6%]和 7.5%[标准差 8.1%]；P=0.02）；12 个月时，未暴露组分别有 71.0%和 41.2%的患者达到了≥5%和≥10%的减重，而暴露组分别为 63.1%和 31.8%（5%时 P=0.04；10%时 P=0.02）。
在接受医学管理的超重和肥胖患者中，暴露于精神药物与减重减少相关。
