Gabrielsen T O, Brandtzaeg P, Hoel P S, Dale I
Laboratory for Immunohistochemistry and Immunopathology, National Hospital, Oslo, Norway.
Br J Dermatol. 1988 Jan;118(1):59-67. doi: 10.1111/j.1365-2133.1988.tb01750.x.
The distribution of LI antigen in four common skin tumours was examined immunohistochemically in 40 samples of formalin-fixed routine biopsy material. Presence of LI in the dermis depended on the extent and composition of the inflammatory infiltrate; LI was found mainly in reactive histiocytes and neutrophils. Intense epidermal staining was seen adjacent to squamous cell carcinoma, basal cell carcinoma and malignant melanoma, but not adjacent to melanocytic naevi. In specimens of melanocytic naevi, LI staining around pilosebaceous units was weak or absent. Around the three malignant types of lesion, epidermal LI positivity faded distally--thereby indicating the extent of the tumour. LI was, in addition, expressed by the most highly differentiated cells in squamous cell carcinomas, whereas the other neoplasms were negative. Antibody to LI may, thus, be a useful adjunct for distinction between various types of skin tumours.
采用免疫组织化学方法对40份福尔马林固定的常规活检材料样本进行检测，以研究LI抗原在四种常见皮肤肿瘤中的分布情况。真皮中LI的存在取决于炎性浸润的程度和组成；LI主要存在于反应性组织细胞和中性粒细胞中。在鳞状细胞癌、基底细胞癌和恶性黑色素瘤附近可见强烈的表皮染色，但在黑素细胞痣附近未见。在黑素细胞痣标本中，皮脂腺单位周围的LI染色较弱或无染色。在三种恶性病变周围，表皮LI阳性向远端逐渐减弱，从而表明肿瘤的范围。此外，鳞状细胞癌中分化程度最高的细胞表达LI，而其他肿瘤为阴性。因此，LI抗体可能是区分各种类型皮肤肿瘤的有用辅助手段。
