蒂尔堡衰弱指标（TFI）对伊朗老年人早期衰弱检测的诊断准确性。
Diagnostic accuracy of the Tilburg Frailty Indicator (TFI) for early frailty detection in elderly people in Iran.
作者信息
Mazoochi Faezeh, Gobbens Robbert J J, Lotfi Mohammad-Sajjad, Fadayevatan Reza
机构信息
Iranian Research Center on Ageing, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Rotterdam University of Applied Sciences, Museumpark 40, 3015 CX, Rotterdam, the Netherlands; Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Amsterdam, the Netherlands.; Zonnehuisgroep Amstelland, Amstelveen, the Netherlands.; Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
出版信息
Arch Gerontol Geriatr. 2020 Nov/Dec;91:104187. doi: 10.1016/j.archger.2020.104187. Epub 2020 Jul 15.
AIM
Screening is one of the most important ways for early frailty detection that contributes to its prevention and timely treatment. The aim of this study was to determine the diagnostic value of the Persian version of the Tilburg Frailty Indicator (P-TFI) in the frailty screening.
METHOD
This is a diagnostic test accuracy study that uses known group method. It was designed based on a STARD statement and performed on 175 elderly people in the City of Kashan, Iran. The subjects were selected among older people available in health centers affiliated to Kashan University of Medical Sciences using purposive sampling. Data analysis was carried out using SPSS v16. Descriptive statistics were used to describe the characteristics of the research subjects. Independent t-test was used to determine the ability of the P-TFI to discriminate frail and non-frail individuals, and to evaluate the cut-off point and instrument accuracy, the receiver operating characteristic (ROC) curve was used. The best cut-off point was determined among the proposed points using Youden index. At the determined cut-off point, the diagnostic value parameters of the P-TFI (sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, accuracy, and diagnostic odds ratio) were calculated and their range was estimated with 95 % confidence interval.
FINDINGS
A total of 74.3 % of the sample was male and their mean age was 68.6 ± 54.44 years. The area under the ROC curve was calculated 0.922, indicating high accuracy of the instrument. The sensitivity and specificity of this instrument at the cut-off point of 4.5 were 0.95 and 0.86, respectively. Positive and negative predictive values were calculated 0.68 and 0.98, respectively, and the accuracy of the instrument was reported to be 0.88.
CONCLUSION
The P-TFI can be used as a sensitive and accurate instrument, which is highly applicable to screen frailty in older people.
目的
筛查是早期衰弱检测的最重要方法之一，有助于预防和及时治疗衰弱。本研究的目的是确定波斯语版蒂尔堡衰弱指标（P-TFI）在衰弱筛查中的诊断价值。
方法
这是一项采用已知组方法的诊断试验准确性研究。该研究基于STARD声明设计，对伊朗卡尚市的175名老年人进行。研究对象通过立意抽样从卡尚医科大学附属健康中心的老年人中选取。使用SPSS v16进行数据分析。描述性统计用于描述研究对象的特征。独立t检验用于确定P-TFI区分衰弱和非衰弱个体的能力，为评估截断点和工具准确性，使用了受试者工作特征（ROC）曲线。使用约登指数在建议的点中确定最佳截断点。在确定的截断点处，计算P-TFI的诊断价值参数（敏感性、特异性、阳性预测值、阴性预测值、阳性似然比、准确性和诊断比值比），并以95%置信区间估计其范围。
结果
样本中共有74.3%为男性，他们的平均年龄为68.6±54.44岁。计算得出ROC曲线下面积为0.922，表明该工具具有较高的准确性。该工具在截断点为4.5时的敏感性和特异性分别为0.95和0.86。阳性和阴性预测值分别计算为0.68和0.98，该工具的准确性报告为0.88。
结论
P-TFI可作为一种敏感且准确的工具，非常适用于筛查老年人的衰弱情况。
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