打开 MCU 让钙离子流动。
Uncorking MCU to let the calcium flow.
机构信息
Departments of Physiology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
出版信息
Cell Calcium. 2020 Nov;91:102257. doi: 10.1016/j.ceca.2020.102257. Epub 2020 Jul 28.
Abstract
New cryo-electron microscopy structures of the mitochondrial Ca uniporter ion channel complex in various conformations reveal channel gating regulation by Ca-dependent unblock of the channel pore by MICU1.
摘要
新的线粒体钙单向转运蛋白离子通道复合物的冷冻电子显微镜结构处于不同构象，揭示了钙离子依赖的 MICU1 对通道孔的非阻塞作用对通道门控的调节。
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