Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Department of Orthopedic, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
J Recept Signal Transduct Res. 2021 Apr;41(2):188-195. doi: 10.1080/10799893.2020.1805625. Epub 2020 Aug 10.
Multiple studies have assessed the contribution of rs10490924 on chromosome 10q26 surrounding gene to age-related macular degeneration (AMD) risk. However, the causal allele at this locus is still inconclusive. In this meta-analysis, we systematically characterized the potential association between rs10490924 polymorphism and AMD risk. Data available from 12 case-control studies, including a total of 5244 cases and 2755 controls in three different ethnic populations, were used to evaluate the correlation between rs10490924 G/T polymorphism (Ala69Ser) and AMD risk. In overall populations, the results indicated the Ala69Ser polymorphism was significantly associated with AMD under allelic (OR = 0.35, 95% CI = 0.30-0.40), homozygous (OR = 0.12, 95%CI = 0.09-0.17), dominant (OR = 0.18, 95%CI = 0.14-0.24), recessive (OR = 0.33, 95%CI = 0.28-0.39), and heterozygous genetic models (OR = 0.26, 95% CI = 0.21-0.33). Similar results were observed in subgroup analysis. This meta-analysis suggests that rs10490924 (Ala69Ser) polymorphism was significantly associated with the susceptibility of AMD in all ethnicities, Ala69 carriers are resistant to AMD risk.
多项研究评估了 10 号染色体 q26 周围基因 rs10490924 对年龄相关性黄斑变性 (AMD) 风险的贡献。然而，该基因座的因果等位基因仍不确定。在这项荟萃分析中，我们系统地描述了 rs10490924 多态性与 AMD 风险之间的潜在关联。从 12 项病例对照研究中获得的数据，包括来自三个不同种族群体的 5244 例病例和 2755 例对照，用于评估 rs10490924 G/T 多态性（Ala69Ser）与 AMD 风险之间的相关性。在总体人群中，结果表明 Ala69Ser 多态性与 AMD 显著相关，在等位基因（OR = 0.35，95%CI = 0.30-0.40）、纯合子（OR = 0.12，95%CI = 0.09-0.17）、显性（OR = 0.18，95%CI = 0.14-0.24）、隐性（OR = 0.33，95%CI = 0.28-0.39）和杂合子遗传模型（OR = 0.26，95% CI = 0.21-0.33）中均如此。亚组分析也观察到了相似的结果。这项荟萃分析表明，rs10490924（Ala69Ser）多态性与所有种族的 AMD 易感性显著相关，Ala69 携带者对 AMD 风险具有抗性。
