非高密度脂蛋白胆固醇升高与儿童肾结石风险增加相关。
Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children.
机构信息
Department of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China.
出版信息
BMC Urol. 2020 Aug 10;20(1):120. doi: 10.1186/s12894-020-00691-6.
BACKGROUND
Dyslipidemia contributes to the development of nephrolithiasis in adults; however its relationship to urolithiasis in children remains debatable, and will be clarified in the present work.
METHODS
A case-control study was performed involving 58 pediatric patients diagnosed with upper urinary tract stones as well as 351 controls. Age, gender, body mass index (BMI), serum calcium, serum uric acid, blood glucose, blood lipids, and compositions of stones were compared.
RESULTS
According to the univariate analysis, uric acid was higher (P < 0.01) but serum calcium lower in the stone group than the control (P < 0.05). As for the blood lipids, non-high-density lipoprotein cholesterol (non-HDL-c) was significantly higher in the stone group as compared to the control (P < 0.01), while total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol did not show statistical difference between the two groups. In the multivariate analysis, only non-HDL-c and serum uric acid were increased in the stone group (P = 0.003 and P = 0.008). In the stone compositions' analysis, serum uric acid and non-HDL-c were associated with percentage of uric acid and pure calcium oxalate stones, respectively.
CONCLUSION
Non-high-density lipoprotein cholesterol may act as a lipid risk factor for urolithiasis in children.
背景
血脂异常会导致成年人肾结石的发生；然而，其与儿童尿石症的关系仍存在争议，本研究将对此进行阐明。
方法
进行了一项病例对照研究，共纳入 58 例被诊断为上尿路结石的儿科患者和 351 例对照。比较了年龄、性别、体重指数（BMI）、血清钙、血清尿酸、血糖、血脂以及结石成分。
结果
单因素分析显示，结石组的尿酸水平较高（P<0.01），而血清钙水平较低（P<0.05）。就血脂而言，与对照组相比，结石组的非高密度脂蛋白胆固醇（non-HDL-c）显著升高（P<0.01），而总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇在两组间无统计学差异。多因素分析显示，仅非高密度脂蛋白胆固醇和血清尿酸在结石组中升高（P=0.003 和 P=0.008）。在结石成分分析中，血清尿酸和非高密度脂蛋白胆固醇分别与尿酸百分比和纯草酸钙结石相关。
结论
非高密度脂蛋白胆固醇可能是儿童尿石症的一个脂质危险因素。
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