Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Radiotherapy and Radiooncology, Outpatient Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28352. doi: 10.1002/pbc.28352. Epub 2020 Aug 11.
Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed by surgical resection for local tumor control and consolidation local control to metastatic sites. Radiotherapy is reserved for cases with a marginal or incomplete resection or for definitive treatment in the case of unresectable disease. We present supporting data for the role of chemotherapy, surgery, and radiation therapy.
骨肉瘤是一种罕见的肿瘤，需要复杂的多学科管理。本文由北美儿童肿瘤协作组和国际儿童肿瘤学会合作，回顾了北美和欧洲骨肉瘤的一般管理和标准放疗指南。标准治疗包括多药诱导化疗，然后进行手术切除以控制局部肿瘤，并对转移部位进行局部巩固治疗。放疗保留用于边缘或不完全切除的病例，或用于不可切除疾病的确定性治疗。我们提供了支持化疗、手术和放疗作用的数据。
