Gambardella Jessica, Khondkar Wafiq, Morelli Marco Bruno, Wang Xujun, Santulli Gaetano, Trimarco Valentina
Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine-Montefiore University Hospital, New York City, NY 10461, USA.
Department of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York City, NY 10461, USA.
Biomedicines. 2020 Aug 6;8(8):277. doi: 10.3390/biomedicines8080277.
Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
精氨酸（L-精氨酸）是一种参与多种生物过程的氨基酸，包括蛋白质的生物合成、宿主免疫反应、尿素循环和一氧化氮的产生。在本系统综述中，我们聚焦于精氨酸在调节内皮功能和血管张力方面的功能作用。我们对临床和临床前研究均进行了考察，分析了补充精氨酸在高血压、缺血性心脏病、衰老、外周动脉疾病和糖尿病中的作用。
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