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Arginine and Endothelial Function.

作者信息

Gambardella Jessica, Khondkar Wafiq, Morelli Marco Bruno, Wang Xujun, Santulli Gaetano, Trimarco Valentina

机构信息

Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine-Montefiore University Hospital, New York City, NY 10461, USA.

Department of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York City, NY 10461, USA.

出版信息

Biomedicines. 2020 Aug 6;8(8):277. doi: 10.3390/biomedicines8080277.

DOI:10.3390/biomedicines8080277
PMID:32781796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7460461/
Abstract

Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c368/7460461/6dfd3a1d4aef/biomedicines-08-00277-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c368/7460461/af1e16b07aea/biomedicines-08-00277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c368/7460461/6dfd3a1d4aef/biomedicines-08-00277-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c368/7460461/af1e16b07aea/biomedicines-08-00277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c368/7460461/6dfd3a1d4aef/biomedicines-08-00277-g002.jpg

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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Nutrients. 2025-2-13

[8]
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[9]
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[10]
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本文引用的文献

[1]
SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases.

Br J Dermatol. 2020-8-5

[2]
Serum Metabolic Signatures of Chronic Limb-Threatening Ischemia in Patients with Peripheral Artery Disease.

J Clin Med. 2020-6-16

[3]
COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern.

AJNR Am J Neuroradiol. 2020-6-18

[4]
Endotheliitis and Endothelial Dysfunction in Patients with COVID-19: Its Role in Thrombosis and Adverse Outcomes.

J Clin Med. 2020-6-15

[5]
The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection.

Crit Care. 2020-6-16

[6]
Diffuse alveolar damage (DAD) resulting from coronavirus disease 2019 Infection is Morphologically Indistinguishable from Other Causes of DAD.

Histopathology. 2020-9-12

[7]
Intracerebral haemorrhage and COVID-19: Clinical characteristics from a case series.

Brain Behav Immun. 2020-6-7

[8]
Dysfunctional Coagulation in COVID-19: From Cell to Bedside.

Adv Ther. 2020-7

[9]
Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II.

Pharmacology. 2020

[10]
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

N Engl J Med. 2020-5-21

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