From the Department of Neuroradiology (R.H., G.K., J.-P.P., O.O.), University Hospital of Lille, Hôpital Roger Salengro, Lille, France
Departments of Interventional Radiology (R.H.), Cardiothoracic, Vascular and Respiratory Intensive Care (P.-A.R.), Neurology and Neurophysiology (B.P.), and Neuroradiology (N.D., F.D., D.M., J.-M.C.), University Hospital of Amiens, Amiens, France.
AJNR Am J Neuroradiol. 2020 Aug;41(8):1384-1387. doi: 10.3174/ajnr.A6651. Epub 2020 Jun 18.
Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of "endotheliitis" associated with this novel coronavirus.
新型冠状病毒病 2019（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的病毒性感染，它在人与人之间迅速传播，在大多数有症状的患者中表现为类似于先前 SARS 病毒的呼吸道疾病。COVID-19 的神经系统表现并不常见；迄今为止报告的有脑病、大血管闭塞性中风和多发性神经病。我们报告了 COVID-19 的一种独特的神经系统并发症，患者广泛存在脑小血管缺血性病变，在缺血、出血和点状对比后增强的特征性联合成像模式中类似于脑血管炎。此外，我们的患者还存在特征性的下肢皮疹。我们的观察结果支持与这种新型冠状病毒相关的“血管内皮炎”的日益怀疑的机制。
