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一名老年男性由伯基特淋巴瘤引起的复发性小肠梗阻:病例报告及文献复习

Recurrent small bowel obstruction caused by Burkitt lymphoma in an elderly man: a case report and review of the literature.

作者信息

Kasparian Saro, Burns Ethan, Shehabeldin Ahmed, Awar Melina, Pingali Sai Ravi

机构信息

Department of Internal Medicine, Houston Methodist Hospital, Houston, TX, 77030, USA.

Department of Pathology, Houston Methodist Hospital, Houston, TX, 77030, USA.

出版信息

J Med Case Rep. 2020 Aug 12;14(1):127. doi: 10.1186/s13256-020-02449-y.

Abstract

BACKGROUND

Acute small bowel obstruction is a common surgical emergency usually caused by abdominal adhesions, followed by intraluminal tumors from metastatic disease. Although lymphomas have been known to cause bowel obstruction, Burkitt lymphoma is seldom reported to induce an obstruction in the adult population.

CASE PRESENTATION

A 78-year-old Hispanic man with a history of abdominal interventions presented to our hospital with abdominal pain. Computed tomography revealed a partial small bowel obstruction attributed to local inflammation or adhesions. Medical management with bowel rest and nasogastric decompression resulted in resolution of symptoms and quick discharge. He returned 2 days later with worsening abdominal pain. Repeat imaging showed progression of the partial small bowel obstruction, but with an additional 1.6-cm nodular density abutting the anterior aspect of the gastric antrum and lobulated anterior gastric antral wall thickening. He was taken to the operating room, where several masses were found. Intraoperative frozen sections were consistent with lymphoma, and pathology later revealed Burkitt lymphoma. Disease was found on both sides of the diaphragm by positron emission tomography. After the initial resection and adjuvant chemotherapy, the patient is alive and well about 14 months after resection.

CONCLUSIONS

Small bowel obstruction is uncommonly due to Burkitt lymphoma in the geriatric population and is more frequently seen in the pediatric and young adult populations. Burkitt lymphoma is very aggressive with rapid cell turnover leading to significant morbidity. The rapid recurrence of an acute abdominal process should prompt an investigation for a more sinister cause such as malignancy.

摘要

背景

急性小肠梗阻是一种常见的外科急症,通常由腹部粘连引起,其次是转移性疾病导致的腔内肿瘤。虽然已知淋巴瘤可导致肠梗阻,但伯基特淋巴瘤很少报道在成年人群中引起梗阻。

病例介绍

一名78岁有腹部手术史的西班牙裔男性因腹痛就诊于我院。计算机断层扫描显示部分小肠梗阻归因于局部炎症或粘连。通过肠道休息和鼻胃减压的内科治疗使症状缓解并迅速出院。两天后他因腹痛加重再次就诊。重复影像学检查显示部分小肠梗阻进展,但在胃窦前壁有一个额外的1.6厘米结节状密度影,胃窦前壁呈分叶状增厚。他被送往手术室,术中发现多个肿块。术中冰冻切片结果与淋巴瘤相符,病理检查后来显示为伯基特淋巴瘤。正电子发射断层扫描发现双侧膈肌均有病变。在初次切除和辅助化疗后,患者在切除术后约14个月时存活且状况良好。

结论

在老年人群中,小肠梗阻很少由伯基特淋巴瘤引起,而在儿童和年轻成人中更常见。伯基特淋巴瘤极具侵袭性,细胞更新迅速,导致严重的发病率。急性腹部疾病的快速复发应促使对更险恶的病因如恶性肿瘤进行调查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/542e/7422579/404243be1c6a/13256_2020_2449_Fig1_HTML.jpg

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