MacLachlan N J, Breitschwerdt E B, Chambers J M, Argenzio R A, De Buysscher E V
Department of Microbiology, School of Veterinary Medicine, North Carolina State University, Raleigh.
Vet Pathol. 1988 Jan;25(1):36-41. doi: 10.1177/030098588802500105.
Intestinal digestive and absorptive function and the gross and histologic appearance of the gastrointestinal tract were evaluated in Basenji dogs with chronic diarrhea, asymptomatic Basenji dogs, and healthy control dogs. Gastric rugal hypertrophy, lymphocytic gastritis, and gastric mucosal atrophy occurred in asymptomatic and affected Basenji dogs. All affected dogs had moderate or severe intestinal lesions characterized by villous clubbing and fusion, increased tortuosity of intestinal crypts, and diffuse infiltration of mononuclear inflammatory cells. Intestinal lesions in asymptomatic Basenji dogs invariably were less severe than those in affected dogs, but the small intestinal lamina propria of asymptomatic Basenji dogs consistently contained greater numbers of mononuclear inflammatory cells than did that of control dogs. The proportion of cells containing each immunoglobulin isotype (IgG, IgM, IgA) was similar among affected Basenji dogs, asymptomatic Basenji dogs, and control dogs. As compared to healthy beagle controls, intestinal function was abnormal in both affected and asymptomatic Basenji dogs evaluated by combined N-benzoyl-L-tyrosyl-p-aminobenzoic acid and d-xylose test, but malabsorption and maldigestion were most pronounced in affected Basenji dogs.
对患有慢性腹泻的巴仙吉犬、无症状巴仙吉犬和健康对照犬的肠道消化和吸收功能以及胃肠道的大体和组织学外观进行了评估。无症状和患病的巴仙吉犬出现胃皱襞肥大、淋巴细胞性胃炎和胃黏膜萎缩。所有患病犬均有中度或重度肠道病变，其特征为绒毛杵状变和融合、肠隐窝迂曲增加以及单核炎性细胞弥漫浸润。无症状巴仙吉犬的肠道病变总是比患病犬轻，但无症状巴仙吉犬的小肠固有层始终比对照犬含有更多的单核炎性细胞。在患病巴仙吉犬、无症状巴仙吉犬和对照犬中，含有每种免疫球蛋白同种型（IgG、IgM、IgA）的细胞比例相似。与健康的比格犬对照相比，通过联合N-苯甲酰-L-酪氨酰对氨基苯甲酸和d-木糖试验评估，患病和无症状巴仙吉犬的肠道功能均异常，但患病巴仙吉犬的吸收不良和消化不良最为明显。
