Mann D L, Foale R A, Gillam L D, Schoenfeld D, Newell J, Weyman A E
Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston.
Am Heart J. 1988 Mar;115(3):538-46. doi: 10.1016/0002-8703(88)90801-0.
Existing studies provide conflicting information concerning the natural history of regional dysfunction after subacute myocardial infarction. The purpose of this study was to use quantitative computer-assisted two-dimensional echocardiography to define the natural history of abnormal wall motion in a subacute canine infarct model within individual short-axis echocardiographic planes, and in the entire ventricle as well. Serial short-axis echocardiograms were obtained from 10 closed-chest dogs before occlusion and at 0.5, 6, 24, 48, and 72 hours after ligation of the circumflex (six dogs) or left anterior descending (four dogs) coronary artery. The circumferential extent of abnormal wall motion was quantified by two different computer-assisted methods: the first, a derived correlation method, examined wall motion throughout the systolic contraction sequence; the second method examined the fractional radial change in endocardial ray length from end-diastole to end-systole. The study shows that for individual planes there is a slight but not statistically significant increase in the circumferential extent of abnormal wall motion from 0.5 to 72 hours after coronary artery occlusion; however, when the total extent of left ventricular asynergy was used to define a global functional infarct size, we observed a small (3.6% to 5.4%) but significant increase in the circumferential extent of abnormal wall motion.
现有研究关于亚急性心肌梗死后局部功能障碍的自然病史提供了相互矛盾的信息。本研究的目的是使用定量计算机辅助二维超声心动图来确定亚急性犬梗死模型中，在个体短轴超声心动图平面内以及整个心室中异常壁运动的自然病史。对10只开胸犬在冠状动脉左旋支（6只犬）或左前降支（4只犬）结扎前以及结扎后0.5、6、24、48和72小时获取连续的短轴超声心动图。通过两种不同的计算机辅助方法对异常壁运动的圆周范围进行量化：第一种是衍生相关方法，检查整个收缩期收缩序列中的壁运动；第二种方法检查从舒张末期到收缩末期心内膜射线长度的径向变化分数。研究表明，对于各个平面，冠状动脉闭塞后0.5至72小时异常壁运动的圆周范围有轻微但无统计学意义的增加；然而，当使用左心室协同失调的总范围来定义整体功能性梗死大小时，我们观察到异常壁运动的圆周范围有小幅度（3.6%至5.4%）但显著的增加。
