Yasmineh W G, Killeen A A, Filipovich A H
Department of Laboratory Medicine University of Minnesota Medical School Minneapolis.
Arch Pathol Lab Med. 1988 Mar;112(3):245-50.
Although it has long been recognized that hyperbilirubinemia is enhanced in patients with impaired renal function, a clear correlation between the levels of bilirubin and creatinine in serum has never been established. We have studied this relationship in 13 bone marrow transplant recipients who had episodes of combined conjugated hyperbilirubinemia and renal impairment. Most of the patients had graft-vs-host disease and various degrees of hepatic cholestasis as evidenced by histologic examination results and abnormal liver function tests. Serial serum specimens obtained during this period showed a good correlation between the two analytes, with a mean (+/- SD) correlation coefficient of .86 +/- .10. The slopes of the regression lines, represented as bilirubin-creatinine ratios, varied widely (0.2 to 3.6), reflecting the wide variation in the degree of hyperbilirubinemia attributable to renal impairment.
尽管长期以来人们已经认识到肾功能受损患者的高胆红素血症会加重，但血清胆红素水平与肌酐水平之间从未建立明确的相关性。我们对13例骨髓移植受者进行了研究，这些患者同时出现了结合胆红素血症和肾功能损害。大多数患者患有移植物抗宿主病以及不同程度的肝内胆汁淤积，组织学检查结果和肝功能异常证实了这一点。在此期间采集的系列血清标本显示，这两种分析物之间具有良好的相关性，平均（±标准差）相关系数为0.86±0.10。以胆红素-肌酐比值表示的回归线斜率差异很大（0.2至3.6），反映了肾功能损害所致高胆红素血症程度的广泛差异。
