Piller N B, Morgan R G, Casley-Smith J R
Department of Surgery, Flinder's Medical Centre, Bedford Park, South Australia.
Br J Plast Surg. 1988 Jan;41(1):20-7. doi: 10.1016/0007-1226(88)90139-7.
A randomised, double-blind, cross-over trial was performed on 26 patients with postmastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took 0-(beta-hydroxyethyl)-rutosides (oxerutin; "Paroven", "Venoruton", Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p less than 0.05 to 0.01) and their circumferences (p less than 0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p less than 0.01 to 0.001). There was a lowering of the elevated skin temperatures (p less than 0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p less than 0.05 to 0.01), and an increased mobility of their limbs (p less than 0.0001). Most patients (70%) preferred the active drug (p less than 0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for placebo (p less than 0.0001).
对26例手臂乳房切除术后淋巴水肿患者和14例腿部淋巴水肿患者进行了一项随机、双盲、交叉试验。患者连续6个月每天服用3克0-(β-羟乙基)-芦丁（奥昔芦丁；“羟苯磺酸钙胶囊”、“威力坦”、Zyma）或安慰剂，然后交换服用。每月进行一次测量（体积、周长、张力测量和皮肤温度）。活性药物可减少肢体体积（p<0.05至0.01）及其周长（p<0.05至0.001）。如张力测量值增加所示，它增加了肢体的柔软度（p<0.01至0.001）。皮肤温度升高有所降低（p<0.05至0.001）。患者报告舒适度和活动自由度增加，胀痛、沉重感和紧张感减轻（p<0.05至0.01），肢体活动度增加（p<0.0001）。大多数患者（70%）更喜欢活性药物（p<0.0001）。97%服用活性药物的患者报告总体健康状况有所改善，而服用安慰剂的患者为4%（p<0.0001）。
