Zhang Ping, Wang Guihua, Gui Yongkun, Guo Zhenfang, Ren Ruifang, Sun Yuying, Song Jinggui
Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, People's Republic of China.
Department of Neurology, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, People's Republic of China.
Nutr Neurosci. 2022 Apr;25(4):737-745. doi: 10.1080/1028415X.2020.1806191. Epub 2020 Aug 13.
The influence of vaspin on vascular health had been investigated, yielding conflicting results. This study is intended to investigate the relation between vaspin and stroke severity and stroke outcome in a cohort Chinese patient with acute ischemic stroke (AIS). This was a prospective single-center observational study in Xinxiang, China. From 1 July 2017 to 30 November 2019, all patients with first-ever AIS were consecutively included. Serum levels of vaspin, stroke severity at (assessed by NIHSS score) admission and functional outcome (assessed by modified Rankin Scale (mRS)) at discharge were recorded. Multivariate analyses were assessed using logistic regression models. Finally, 340 patients with AIS were included. The median age of those patients was 65 (interquartile range [IQR], 56-74) years and 61.8% were men. At admission, 88 patients (25.9%) experienced severe stroke (NIHSS>10) and serum levels of vaspin (median [IQR]: 0.72[0.48-0.90]ng/ml) in those patients were significantly lower than in those mild(0.92[0.70-1.19]ng/ml) and moderate stroke (0.93[0.63-1.21]ng/ml). At discharge, 113 patients (33.2%) experienced poor functional outcome (mRS >2) and vaspin serum levels in those patients were lower as compared with patients who experienced good outcome (0.71[0.45-0.98] vs. 0.91[0.71-1.19]ng/ml). In multivariate analyses, lower level of vaspin (< median) was associated with a 2.5-fold (odds ratio [OR] 2.46; 95% confidence interval [CI]: 1.75-4.45) increased risk for severe stroke and a 2.1-fold (2.03; 1.42-3.58) increased risk for poor outcome. In conclusion, reduced serum levels of vaspin at admission are significantly related to stroke severity and prognosis, which illustrates a predictive role of reduced vaspin in ischemic stroke.
已有研究探讨了内脏脂肪素对血管健康的影响，结果相互矛盾。本研究旨在调查中国急性缺血性脑卒中（AIS）患者队列中内脏脂肪素与卒中严重程度及卒中结局之间的关系。这是一项在中国新乡进行的前瞻性单中心观察性研究。2017年7月1日至2019年11月30日，连续纳入所有首次发生AIS的患者。记录内脏脂肪素的血清水平、入院时的卒中严重程度（通过美国国立卫生研究院卒中量表（NIHSS）评分评估）以及出院时的功能结局（通过改良Rankin量表（mRS）评估）。使用逻辑回归模型进行多变量分析。最终，纳入了340例AIS患者。这些患者的中位年龄为65岁（四分位间距[IQR]，56 - 74岁），男性占61.8%。入院时，88例患者（25.9%）发生严重卒中（NIHSS>10），这些患者的内脏脂肪素血清水平（中位数[IQR]：0.72[0.48 - 0.90]ng/ml）显著低于轻度卒中患者（0.92[0.70 - 1.19]ng/ml）和中度卒中患者（0.93[0.63 - 1.21]ng/ml）。出院时，113例患者（33.2%）功能结局较差（mRS>2），这些患者的内脏脂肪素血清水平低于功能结局良好的患者（0.71[0.45 - 0.98]与0.91[0.71 - 1.19]ng/ml）。在多变量分析中，较低水平的内脏脂肪素（<中位数）与严重卒中风险增加2.5倍（比值比[OR]2.46；95%置信区间[CI]：1.75 - 4.45）以及不良结局风险增加2.1倍（2.03；1.42 - 3.58）相关。总之，入院时内脏脂肪素血清水平降低与卒中严重程度和预后显著相关，这表明内脏脂肪素降低在缺血性卒中中具有预测作用。
