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2
SIPA1 Is a Modulator of HGF/MET Induced Tumour Metastasis via the Regulation of Tight Junction-Based Cell to Cell Barrier Function.SIPA1是通过调节紧密连接介导的细胞间屏障功能来调控HGF/MET诱导的肿瘤转移的一种调节剂。
Cancers (Basel). 2021 Apr 6;13(7):1747. doi: 10.3390/cancers13071747.
3
Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility.SIPA1基因多态性与散发性乳腺癌易感性
BMC Cancer. 2009 Sep 18;9:331. doi: 10.1186/1471-2407-9-331.
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Expression of signal-induced proliferation-associated gene 1 (SIPA1), a RapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells.信号诱导增殖相关基因 1（SIPA1）表达增加，SIPA1 是一种 RapGTPase 激活蛋白，在结直肠癌中表达增加，并对结直肠癌细胞的功能有多种影响。
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Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.SIPA1基因的种系多态性与乳腺癌转移及其他预后不良指标相关。
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Heliyon. 2024 Jan 17;10(2):e24869. doi: 10.1016/j.heliyon.2024.e24869. eCollection 2024 Jan 30.
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4
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Cancers (Basel). 2021 Apr 6;13(7):1747. doi: 10.3390/cancers13071747.

本文引用的文献

1
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.磷脂酰肌醇3激酶、生长紊乱与癌症
N Engl J Med. 2018 Nov 22;379(21):2052-2062. doi: 10.1056/NEJMra1704560.
2
Dynamic relationship between SIPA1 gene and protein expression and the development of gastric cancer.SIPA1基因与蛋白表达之间的动态关系及胃癌的发展
Genet Mol Res. 2017 Mar 16;16(1):gmr-16-01-gmr.16019271. doi: 10.4238/gmr16019271.
3
TGF-β Family Signaling in Tumor Suppression and Cancer Progression.TGF-β 家族信号在肿瘤抑制和癌症进展中的作用。
Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12):a022277. doi: 10.1101/cshperspect.a022277.
4
SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.SIPA1通过ITGB1和MMP7促进人类口腔鳞状细胞癌的侵袭和迁移。
Exp Cell Res. 2017 Mar 15;352(2):357-363. doi: 10.1016/j.yexcr.2017.02.026. Epub 2017 Feb 22.
5
The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.SIPA1和RRP1B种系多态性对一组立陶宛年轻乳腺癌患者的乳腺癌表型、淋巴结状态及生存的影响。
Biomarkers. 2016;21(4):363-70. doi: 10.3109/1354750X.2016.1141989. Epub 2016 Feb 22.
6
The SIPA1 -313A>G polymorphism is associated with prognosis in inoperable non-small cell lung cancer.SIPA1基因-313A>G多态性与不可切除非小细胞肺癌的预后相关。
Tumour Biol. 2015 Feb;36(2):1273-8. doi: 10.1007/s13277-014-2753-8. Epub 2014 Oct 29.
7
FAK in cancer: mechanistic findings and clinical applications.FAK 在癌症中的作用：机制研究发现与临床应用
Nat Rev Cancer. 2014 Sep;14(9):598-610. doi: 10.1038/nrc3792. Epub 2014 Aug 7.
8
Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells.核 SIPA1 激活整合素 β1 启动子并促进乳腺癌细胞的侵袭。
Oncogene. 2015 Mar 12;34(11):1451-62. doi: 10.1038/onc.2014.36. Epub 2014 Apr 7.
9
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.BRD4短异构体在核膜内表面与RRP1B、SIPA1以及LINC复合物的组分相互作用。
PLoS One. 2013 Nov 19;8(11):e80746. doi: 10.1371/journal.pone.0080746. eCollection 2013.
10
Case-only analyses of the associations between polymorphisms in the metastasis-modifying genes BRMS1 and SIPA1 and breast tumor characteristics, lymph node metastasis, and survival.仅对转移修饰基因 BRMS1 和 SIPA1 中的多态性与乳腺癌肿瘤特征、淋巴结转移和生存之间的关联进行病例对照分析。
Breast Cancer Res Treat. 2013 Jun;139(3):873-85. doi: 10.1007/s10549-013-2601-3. Epub 2013 Jun 16.

SIPA1在癌症发生及转移中的作用（综述）

The role of SIPA1 in the development of cancer and metastases (Review).

作者信息

Liu Chang, Jiang Wen Guo, Hargest Rachel, Martin Tracey Amanda

机构信息

Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

出版信息

Mol Clin Oncol. 2020 Oct;13(4):32. doi: 10.3892/mco.2020.2102. Epub 2020 Jul 29.

DOI:10.3892/mco.2020.2102
PMID:32789016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7416617/
Abstract

Cancer is a leading cause of mortality and the majority of deaths are due to metastases. Many molecules have been implicated in the development of metastases. Signal induced proliferation associated protein 1 (SIPA1), a mitogen-inducible gene, has been demonstrated to be involved in the metastasis of various solid tumours and may indicate a poor prognosis. Polymorphisms of SIPA1 can be associated with several different types of cancer and interactions between SIPA1 and binding molecules integrate a series of cellular functions, which may promote the development and metastasis of cancer. The mechanisms by which SIPA1 promotes the development and metastasis of cancer varies among tumour types. The present review describes the structure, function and regulation of SIPA1 and focuses on its role in cancer metastasis. Possibilities for future research and the clinical application of SIPA1 are also discussed.

摘要

癌症是主要的死亡原因，大多数死亡是由转移所致。许多分子与转移的发生有关。信号诱导增殖相关蛋白1（SIPA1）是一种有丝分裂原诱导基因，已被证明参与各种实体瘤的转移，并且可能预示预后不良。SIPA1的多态性可能与几种不同类型的癌症相关，SIPA1与结合分子之间的相互作用整合了一系列细胞功能，这可能促进癌症的发展和转移。SIPA1促进癌症发展和转移的机制因肿瘤类型而异。本综述描述了SIPA1的结构、功能和调控，并重点关注其在癌症转移中的作用。还讨论了SIPA1未来研究的可能性及其临床应用。