SIPA1在癌症发生及转移中的作用（综述）
The role of SIPA1 in the development of cancer and metastases (Review).
作者信息
Liu Chang, Jiang Wen Guo, Hargest Rachel, Martin Tracey Amanda
机构信息
Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
出版信息
Mol Clin Oncol. 2020 Oct;13(4):32. doi: 10.3892/mco.2020.2102. Epub 2020 Jul 29.
Cancer is a leading cause of mortality and the majority of deaths are due to metastases. Many molecules have been implicated in the development of metastases. Signal induced proliferation associated protein 1 (SIPA1), a mitogen-inducible gene, has been demonstrated to be involved in the metastasis of various solid tumours and may indicate a poor prognosis. Polymorphisms of SIPA1 can be associated with several different types of cancer and interactions between SIPA1 and binding molecules integrate a series of cellular functions, which may promote the development and metastasis of cancer. The mechanisms by which SIPA1 promotes the development and metastasis of cancer varies among tumour types. The present review describes the structure, function and regulation of SIPA1 and focuses on its role in cancer metastasis. Possibilities for future research and the clinical application of SIPA1 are also discussed.
癌症是主要的死亡原因，大多数死亡是由转移所致。许多分子与转移的发生有关。信号诱导增殖相关蛋白1（SIPA1）是一种有丝分裂原诱导基因，已被证明参与各种实体瘤的转移，并且可能预示预后不良。SIPA1的多态性可能与几种不同类型的癌症相关，SIPA1与结合分子之间的相互作用整合了一系列细胞功能，这可能促进癌症的发展和转移。SIPA1促进癌症发展和转移的机制因肿瘤类型而异。本综述描述了SIPA1的结构、功能和调控，并重点关注其在癌症转移中的作用。还讨论了SIPA1未来研究的可能性及其临床应用。
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