基因探针分析表明，同时存在的慢性髓性白血病和慢性淋巴细胞白血病存在独立的克隆进化。
Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia.
作者信息
Browett P J, Pattinson J, Pinkney J, Hoffbrand A V, Norton J D
机构信息
Department of Haematology, Royal Free Hospital, Hampstead, London, U.K.
出版信息
Eur J Haematol. 1988 Feb;40(2):181-4. doi: 10.1111/j.1600-0609.1988.tb00818.x.
We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.
我们描述了一例69岁男性同时发生费城染色体阳性慢性髓性白血病和B细胞慢性淋巴细胞白血病的病例。对来自外周血和骨髓的DNA进行基因探针分析，为该病例中两个克隆的独立演化提供了证据，其中主要群体显示免疫球蛋白重链基因重排，较小群体显示22号染色体断裂簇区域内的重排。
Zotero 插件