Trofimova S A, Balunov O A, Dubinina E E
BekhterevNational Research Medical Center of Psychiatry and Neurology, St. Peterburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(7):44-49. doi: 10.17116/jnevro202012007144.
To study the use of combination therapy for post-stroke depression using antidepressants and antioxidants.
The dynamics of the clinical status of post-stroke depression and parameters of oxidative stress were evaluated in 60 patients with post-stroke depression before and after a 3-month treatment with fluvoxamine in a daily dose of 100 mg per day and cytoflavin in a dose of 10 ml/day (200 ml of 5% glucose solution or physiological saline in patients with diabetes mellitus) intravenously in the morning for 10 days followed by transfer to tablet form (2 tabs in the morning and 2 tabs in the evening for 90 days).
The results on the comparative effectiveness of the treatment of post-stroke depression with fluvoxamine monotherapy and the combination of fluvoxamine and cytoflavin confirmed the great effectiveness of the combination therapy, which should be taken into account when developing new treatment regimens for post-stroke depression, and the need for prescribing antidepressants and antioxidant drugs should be determined based on an individual assessment of the severity of depressive disorder and parameters of oxidative stress: endogenous antioxidant activities in each individual patient with ischemic stroke.
研究使用抗抑郁药和抗氧化剂联合治疗中风后抑郁症。
对60例中风后抑郁症患者进行评估，在每日口服100mg氟伏沙明及每日静脉注射10ml细胞色素C（糖尿病患者用200ml 5%葡萄糖溶液或生理盐水）共10天，之后转为片剂（早晚各2片，共90天）治疗3个月前后，观察中风后抑郁症的临床状态变化及氧化应激参数。
氟伏沙明单药治疗与氟伏沙明和细胞色素C联合治疗中风后抑郁症的比较有效性结果证实了联合治疗的显著疗效，在制定中风后抑郁症新治疗方案时应予以考虑，且应根据对抑郁症严重程度和氧化应激参数（缺血性中风患者个体内源性抗氧化活性）的个体评估来确定是否需要开具抗抑郁药和抗氧化剂药物。
