Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Diabetes and Bone-metabolic Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark.
Nutr Cancer. 2021;73(9):1816-1820. doi: 10.1080/01635581.2020.1803934. Epub 2020 Aug 13.
Hyperlipidemia is common during contemporary treatment of childhood acute lymphoblastic leukemia and may increase risk of osteonecrosis, thrombosis, and possibly acute pancreatitis. Marine fatty acids found in fish oil decrease levels of triglycerides and possibly total cholesterol in hyperlipidemic patients. This prospective pilot study provided fish oil for 83 days to seven children undergoing acute lymphoblastic leukemia treatment. On average fish oil was consumed 74% of the intervention period. Further, we found significant lower levels of triglycerides ( = 0.016) and total cholesterol ( = 0.027) compared to 22 historical controls, although correction for one extra PEG-asparaginase dose reduced the level of significance. However, the findings indicate that fish oil may alleviate development of hyperlipidemia during acute lymphoblastic leukemia treatment. Randomized controlled trials are warranted to confirm these findings and to investigate the potential effect of fish oil supplements on development of severe adverse events, including osteonecrosis, thrombosis, and acute pancreatitis.
高脂血症在当代儿童急性淋巴细胞白血病的治疗中很常见，可能会增加骨坏死、血栓形成的风险，并且可能会增加急性胰腺炎的风险。鱼油中含有的海洋脂肪酸可降低高脂血症患者的甘油三酯和总胆固醇水平。这项前瞻性的初步研究为 7 名接受急性淋巴细胞白血病治疗的儿童提供了 83 天的鱼油。平均而言，儿童在干预期间摄入了 74%的鱼油。此外，与 22 名历史对照相比，我们发现甘油三酯（=0.016）和总胆固醇（=0.027）水平显著降低，尽管校正 1 个额外的 PEG-天冬酰胺酶剂量后，其水平的显著性降低。然而，这些发现表明，鱼油可能缓解急性淋巴细胞白血病治疗过程中发生的高脂血症。需要进行随机对照试验来证实这些发现，并研究鱼油补充剂对严重不良事件（包括骨坏死、血栓形成和急性胰腺炎）发展的潜在影响。
