早期高潮水疗法：表面活性剂治疗以优化潮气量、肺复张和 iNO 反应。
Surf early to higher tides: surfactant therapy to optimize tidal volume, lung recruitment, and iNO response.
机构信息
Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, WI, 53226, USA.
Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, 95817, USA.
出版信息
J Perinatol. 2021 Jan;41(1):1-3. doi: 10.1038/s41372-020-0764-4. Epub 2020 Aug 13.
Abstract
Inhaled nitric oxide is approved by FDA for the management of hypoxemic respiratory failure in term and near-term infants. However, approximately a third of patients treated with inhaled nitric oxide fail to have a sustained improvement in oxygenation. Recruitment of the lung with surfactant enables optimal delivery of nitric oxide to the alveolar space leading to effective pulmonary vasodilation.
摘要
吸入一氧化氮已获美国食品药品监督管理局批准，用于治疗足月和近足月婴儿低氧性呼吸衰竭。然而，大约三分之一接受吸入一氧化氮治疗的患者的氧合情况未能持续改善。表面活性物质使肺得到复张，从而使一氧化氮能最佳地输送到肺泡空间，导致有效的肺血管扩张。
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