新生儿持续性肺动脉高压的病理生理学和治疗管理。
Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn.
机构信息
Department of Pediatrics - Neonatology and Pediatric Cardiology, Cambridge University Hospitals NHS Foundation Trust and University of Cambridge School of Clinical Medicine, Cambridge, UK; Department of Pediatrics - Division of Neonatology, Loma Linda University Children's Hospital and Loma Linda University School of Medicine, 11175 Coleman Pavillion, Loma Linda, CA 92374, USA.
Department of Pediatrics, UC Davis Children's Hospital, UC Davis Health, Sacramento, CA 95817, USA.
出版信息
Clin Perinatol. 2021 Aug;48(3):595-618. doi: 10.1016/j.clp.2021.05.009.
Persistent pulmonary hypertension of the newborn (PPHN) is a disorder of circulatory transition resulting in high pulmonary vascular resistance with extrapulmonary right-to-left shunts causing hypoxemia. There has been substantial gain in understanding of pathophysiology of PPHN over the past 2 decades, and biochemical pathways responsible for abnormal vasoconstriction of pulmonary vasculature are now better understood. Easy availability of bedside echocardiography helps in establishing early definitive diagnosis, understanding the pathophysiology and hemodynamic abnormalities, monitoring the disease process, and response to therapeutic intervention. There also has been significant advancement in specific management of PPHN targeted at deranged biochemical pathways and hemodynamic instability.
新生儿持续性肺动脉高压（PPHN）是一种循环过渡障碍，导致肺血管阻力升高，伴有肺外右向左分流导致低氧血症。在过去的 20 年中，人们对 PPHN 的病理生理学有了实质性的了解，现在对导致肺血管异常收缩的生化途径有了更好的理解。床边超声心动图的广泛应用有助于早期明确诊断，了解病理生理学和血流动力学异常，监测疾病过程，并对治疗干预做出反应。在针对异常生化途径和血流动力学不稳定的 PPHN 特定治疗方面也取得了重大进展。
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