Michelson E L, Dreifus L S
Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Med Clin North Am. 1988 Mar;72(2):275-319. doi: 10.1016/s0025-7125(16)30772-6.
The effective management of cardiac arrhythmias remains a major challenge in cardiovascular therapeutics. The management of arrhythmias encompasses a wide spectrum of supraventricular and ventricular tachyarrhythmias occurring in patients with various cardiac diagnoses and different degrees of myocardial dysfunction. A number of the newer antiarrhythmic drugs that have either recently been released or appear promising are reviewed in this article. Drugs are described with respect to their basic pharmacology, electrophysiologic actions, pharmacokinetics and metabolism, hemodynamics, antiarrhythmic effects, side effects, interactions, indications, and dosage.
心律失常的有效管理仍然是心血管治疗中的一项重大挑战。心律失常的管理涵盖了各种心脏诊断和不同程度心肌功能障碍患者中出现的广泛室上性和室性快速心律失常。本文综述了一些近期已上市或前景看好的新型抗心律失常药物。对这些药物的基本药理学、电生理作用、药代动力学和代谢、血流动力学、抗心律失常作用、副作用、相互作用、适应症和剂量进行了描述。
