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Commentary: -Cre-Mediated Global Knockout.评论:-Cre介导的全身基因敲除
Front Endocrinol (Lausanne). 2020 Jul 24;11:472. doi: 10.3389/fendo.2020.00472. eCollection 2020.
2
-Cre-Mediated Global Knockout.-cre介导的全基因敲除
J Endocr Soc. 2020 Jan 12;4(2):bvaa001. doi: 10.1210/jendso/bvaa001. eCollection 2020 Feb 1.
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Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues.转位蛋白/外周苯二氮䓬受体在生殖组织中的发育表达。
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Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.TSPO在条件性类固醇生成细胞靶向缺失中揭示了其在细胞活力和激素依赖性类固醇形成中的关键作用。
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The role of steroidogenic factor 1 (SF-1) in steroidogenic cell function of the testes and ovaries of mature mice.类固醇生成因子 1(SF-1)在成熟小鼠睾丸和卵巢类固醇生成细胞功能中的作用。
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Biol Reprod. 2017 Jan 1;97(6):822-834. doi: 10.1093/biolre/iox143.

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1
Single cell resolution of neurosteroidogenesis in the murine brain: de novo biosynthesis.小鼠大脑中神经甾体生成的单细胞分辨率:从头生物合成
J Endocrinol. 2025 May 7;265(3). doi: 10.1530/JOE-24-0318. Print 2025 Jun 1.
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Normal Ovarian Function in Subfertile Mouse with Cre-Driven Ablation of and .具有 Cre 驱动的 和 基因敲除的不育小鼠的正常卵巢功能。
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Steroidogenic factor 1 (SF-1; ) regulates the formation of the ovarian reserve.类固醇生成因子 1(SF-1; )调节卵巢储备的形成。
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The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions.基础状态下完全 TSPO/PBR 敲除小鼠中的全类固醇组库。
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Absence of the mitochondrial translocator protein 18 kDa in mice does not affect body weight or food intake responses to altered energy availability.小鼠中缺乏18 kDa的线粒体转位蛋白不影响体重或对能量供应改变的食物摄入反应。
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STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association.STARD1 在胆固醇代谢和新生 HDL 形成中发挥作用。基因表达和分子 mRNA 成像显示出新型剪接和 1:1 的线粒体关联。
Front Endocrinol (Lausanne). 2020 Oct 20;11:559674. doi: 10.3389/fendo.2020.559674. eCollection 2020.

本文引用的文献

1
-Cre-Mediated Global Knockout.-cre介导的全基因敲除
J Endocr Soc. 2020 Jan 12;4(2):bvaa001. doi: 10.1210/jendso/bvaa001. eCollection 2020 Feb 1.
2
Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.在小鼠中系统性敲除 Tspo 并不影响视网膜形态、功能和易变性。
Exp Eye Res. 2019 Nov;188:107816. doi: 10.1016/j.exer.2019.107816. Epub 2019 Sep 25.
3
CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells.CRISPR-Cas9 介导的 TSPO 基因敲除改变人原代小胶质细胞的呼吸和细胞代谢。
Int J Mol Sci. 2019 Jul 9;20(13):3359. doi: 10.3390/ijms20133359.
4
Deletion of TSPO Resulted in Change of Metabolomic Profile in Retinal Pigment Epithelial Cells.TSPO 缺失导致视网膜色素上皮细胞代谢组学特征发生变化。
Int J Mol Sci. 2019 Mar 19;20(6):1387. doi: 10.3390/ijms20061387.
5
Letter to the Editor: Dubious Conclusions on TSPO Function.致编辑的信:关于TSPO功能的可疑结论。
Endocrinology. 2018 Jul 1;159(7):2528-2529. doi: 10.1210/en.2018-00052.
6
CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells.CRISPR/Cas9介导的Tspo基因突变导致MA-10小鼠肿瘤间质细胞线粒体膜电位降低和类固醇生成减少。
Endocrinology. 2018 Feb 1;159(2):1130-1146. doi: 10.1210/en.2017-03065.
7
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male.转位蛋白敲除小鼠的类固醇生成异常及在老年男性中的意义。
Biochem J. 2018 Jan 2;475(1):75-85. doi: 10.1042/BCJ20170645.
8
Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.Med12 调节哺乳动物卵子中的卵巢类固醇生成、子宫发育和母体效应。
Biol Reprod. 2017 Jan 1;97(6):822-834. doi: 10.1093/biolre/iox143.
9
mutations in rats and a human polymorphism impair the rate of steroid synthesis.大鼠的突变和一种人类多态性会损害类固醇合成的速率。
Biochem J. 2017 Nov 21;474(23):3985-3999. doi: 10.1042/BCJ20170648.
10
Overactivation of hedgehog signaling in the developing Müllerian duct interferes with duct regression in males and causes subfertility.在发育中的苗勒管中,刺猬信号通路的过度激活会干扰雄性苗勒管的退化,并导致生育力低下。
Reproduction. 2017 Apr;153(4):481-492. doi: 10.1530/REP-16-0562. Epub 2017 Jan 25.

Commentary: -Cre-Mediated Global Knockout.

作者信息

Selvaraj Vimal, Morohaku Kanako, Koganti Prasanthi P, Zhang Jianmin, He Wei, Quirk Susan M, Stocco Douglas M

机构信息

Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.

Division of Animal Science, School of Science and Technology, Institute of Agriculture, Shinshu University, Nagano, Japan.

出版信息

Front Endocrinol (Lausanne). 2020 Jul 24;11:472. doi: 10.3389/fendo.2020.00472. eCollection 2020.

DOI:10.3389/fendo.2020.00472
PMID:32793121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7393387/
Abstract
摘要