Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Department of Otolaryngology-Head Neck Surgery, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Radiat Oncol. 2020 Aug 14;15(1):194. doi: 10.1186/s13014-020-01632-1.
We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).
The study sample consisted of 905 patients with surgically treated OCSCC who fulfilled criteria of RT course ≤8 weeks. The study participants were divided into three groups based on the characteristics of missed RT, as follows: 1) early missed RT, 2) late missed RT, and 3) RT as scheduled.
The 5-year overall survival (OS) rates in the early missed RT, late missed RT, and RT as scheduled groups were 53.0, 58.1, and 64.5%, respectively (p = 0.046). In multivariate analysis, early missed RT was independently associated with both OS (hazard ratio (HR) = 1.486; 95% confidence interval (CI): 1.122-1.966; p = 0.006) and the occurrence of distant metastasis (HR = 1.644; 95% CI: 1.047-2.583; p = 0.031).
Early missed RT was independently associated with a higher occurrence of distant metastasis and less favorable OS in patients who had undergone surgery for OCSCC.
我们旨在研究接受口腔鳞状细胞癌（OCSCC）手术治疗的患者中错过放疗（RT）次数对预后的影响。
研究样本包括 905 名接受过手术治疗且满足 RT 疗程≤8 周标准的 OCSCC 患者。研究参与者根据错过 RT 的特征分为三组：1）早期错过 RT，2）晚期错过 RT，和 3）按时 RT。
早期错过 RT、晚期错过 RT 和按时 RT 组的 5 年总生存率（OS）分别为 53.0%、58.1%和 64.5%（p=0.046）。多变量分析显示，早期错过 RT 与 OS（风险比（HR）=1.486；95%置信区间（CI）：1.122-1.966；p=0.006）和远处转移的发生（HR=1.644；95%CI：1.047-2.583；p=0.031）均独立相关。
对于接受 OCSCC 手术治疗的患者，早期错过 RT 与远处转移发生率更高和 OS 更差独立相关。
