Department of Otolaryngology-Head and Neck Surgery, Brooke Army Medical Center, San Antonio, Texas, U.S.A.
Clinical Investigation and Research Support, 59th Medical Wing, United States Air Force, San Antonio, Texas, U.S.A.
Laryngoscope. 2021 Mar;131(3):490-495. doi: 10.1002/lary.29006. Epub 2020 Aug 14.
We sought to determine the time course of clinical and histologic differences between aspirated inorganic and organic foreign bodies.
In-vivo.
Twenty Sinclair miniature swine (Sus scrofa domesticus) were divided into two groups-inorganic or organic foreign bodies. Either an organic (peanut) or an inorganic (Lego) foreign body was placed within a bronchus and left for 3, 5, 7, 14 or 21 days. The airway was reassessed at the predetermined endpoint at which time endoscopic, gross, and histopathological findings were documented. Specimens were scored with a pathologic scoring system to assess injury severity from the foreign body.
Foreign bodies were successfully placed in all 20 swine. Two animals required early euthanasia due to respiratory compromise. The foreign body was identified grossly in eight (40%) animals. An additional three (15%) had microscopic evidence suggestive of a previous foreign body of an undetermined duration. There was no difference in injury severity between organic and inorganic foreign bodies. The 3-day group had injuries limited to the bronchial lining, whereas the longer duration groups had bronchial and adjacent lung parenchymal involvement. There was no difference in injury severity between days 5 and 21.
Airway foreign bodies initially cause bronchial damage. After 5 days, the foreign body causes lung parenchymal changes. There was no difference in airway lesion severity between organic and inorganic foreign bodies.
N/A Laryngoscope, 131:490-495, 2021.
我们旨在确定吸入无机和有机异物之间的临床和组织学差异的时间过程。
体内。
将 20 只 Sinclair 小型猪（Sus scrofa domesticus）分为无机或有机异物两组。将有机（花生）或无机（乐高）异物置于支气管内，分别留置 3、5、7、14 或 21 天。在预定的终点，重新评估气道，记录内镜、大体和组织病理学发现。使用病理评分系统对标本进行评分，以评估异物引起的损伤严重程度。
成功将异物放置在所有 20 只猪中。由于呼吸窘迫，两只动物需要早期安乐死。在八只（40%）动物中大体上识别出异物。另外三只（15%）有提示以前存在异物但时间不确定的微观证据。有机和无机异物的损伤严重程度无差异。3 天组的损伤仅限于支气管内膜，而较长时间组的损伤累及支气管和相邻肺实质。5 天和 21 天之间的损伤严重程度无差异。
气道异物最初会引起支气管损伤。5 天后，异物会引起肺实质改变。有机和无机异物之间的气道病变严重程度无差异。
N/A 喉镜，131：490-495，2021。
