Pirdadeh-Beiranvand Masoumeh, Afkhami Abbas, Madrakian Tayyebeh
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
Talanta. 2020 Oct 1;218:121190. doi: 10.1016/j.talanta.2020.121190. Epub 2020 May 21.
Nickel zinc ferrite (NiZnFeO) nanoparticles decorated poly (vinyl alcohol) was constructed by the electrospinning method and used for determining the sunitinib amount in real sample. In this study, resonance light scattering (RLS) technique was used for studying the interaction of nanofibers with sunitinib. Similar NiZnFeO nanoparticles-decorated nanofibers with average diameter of 200 nm and length up to several millimeters were prepared. The morphology and microstructure of the as prepared Ni Zn FeO nanoparticles-decorated nanofibers were studied in details. The nanofibers were characterized by energy dispersive X-ray spectroscopy, scanning electron microscopy, and transmission electron microscopy techniques. The nanofibers are formed through assembling magnetic nanoparticles with poly (vinyl alcohol) as the structure-directing template. Under the optimal conditions, the linear dynamic range and RSD were 5.0 × 10-10.0 mg L and 1.62% (n = 3), respectively. A limit of detection of 1.0 × 10 mg L sunitinib was obtained from this method. The obtained results showed successful application of the method for the analysis of sunitinib in real samples.
通过静电纺丝法制备了镍锌铁氧体（NiZnFeO）纳米颗粒修饰的聚乙烯醇，并将其用于测定实际样品中舒尼替尼的含量。在本研究中，采用共振光散射（RLS）技术研究纳米纤维与舒尼替尼的相互作用。制备了平均直径为200nm、长度达几毫米的类似NiZnFeO纳米颗粒修饰的纳米纤维。详细研究了所制备的NiZnFeO纳米颗粒修饰纳米纤维的形貌和微观结构。通过能量色散X射线光谱、扫描电子显微镜和透射电子显微镜技术对纳米纤维进行了表征。纳米纤维是通过以聚乙烯醇为结构导向模板组装磁性纳米颗粒形成的。在最佳条件下，线性动态范围和相对标准偏差分别为5.0×10⁻¹⁰.0mg/L和1.62%（n = 3）。该方法对舒尼替尼的检测限为1.0×10mg/L。所得结果表明该方法成功应用于实际样品中舒尼替尼的分析。
