Department of Biological Sciences, Centre for Neuroscience, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, 215123, China.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics- Huazhong University of Science and Technology, Wuhan, 430074, China.
Curr Neuropharmacol. 2021;19(5):665-678. doi: 10.2174/1570159X18666200814180218.
Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.
Src 家族激酶（SFK）是一组非受体酪氨酸激酶，在细胞反应和肿瘤发生中起着关键作用。越来越多的证据表明，SFK 在生理和病理条件下也是中枢神经系统（CNS）信号通路中的关键组成部分。尽管 SFK 在中枢神经系统信号转导中起着至关重要的作用，但 SFK 与涉及疼痛的分子之间的关系尚未得到充分探索。本文简要回顾了最近的研究进展，揭示了 SFK 与中枢神经系统中多种膜蛋白和细胞内蛋白的相互作用，以及 SFK 在偏头痛和神经性疼痛病理生理学中的重要性。还总结了 SFK 在这些情况下的作用机制以及 SFK 抑制剂在神经疾病中的潜在临床应用。我们提出 SFK 是偏头痛和神经性疼痛信号通路的汇聚点，可能成为这些疾病有前途的治疗靶点。
