Oliveira Grazielle Silva De, Iraci Lucio, Pinheiro Gislaine Siqueira, Casal Marcela Zimmermann, Haas Aline Nogueira, Pochmann Daniela, Martinez Flavia Gomes, Elsner Viviane, Dani Caroline
Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS-Brasil.
Laboratório de Pesquisa do Exercício, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS-Brasil.
Physiol Behav. 2020 Dec 1;227:113135. doi: 10.1016/j.physbeh.2020.113135. Epub 2020 Aug 14.
This study aimed to investigate the impact of an aquatic physical training program associated with grape juice (Vitis labrusca) consumption on functional outcomes, Brain-Derived Neurotrophic Factor (BDNF) and global histone H4 acetylation levels in peripheral blood from individuals with Parkinson's disease.
Nineteen participants were randomized to Aquatic Exercise (AQ, n = 9) and Aquatic Exercise + Grape Juice (AQ+GJ, n = 10) groups and performed to 4 weeks of an aquatic intervention (twice a week, approximately 60 min/session). The AQ+GJ groups also consumed 400 mL of grape juice per day during this period. Functional capacity (six-min walk test, 6MWT), mobility (The Timed Up and Go, TUG) and the risk of falls (Berg Balance Scale, BBS) were evaluated before and after intervention. In addition, blood collections were carried out for biomarker analysis (e.g. BDNF and global histone H4).
The aquatic exercise program induced functional improvement in individuals with Parkinson's disease, specifically ameliorating their mobility and functional capacity. In addition, enhanced levels of BDNF and histone H4 acetylation were found after the intervention. Grape juice consumption did not potentiate these effects, since any significant differences between the AQ and AQ+GJ groups were not found in all analysed variables.
The present study provides important insights about aquatic exercise-modulated BDNF levels in individuals with Parkinson's disease in combination with functional improvements, suggesting that histone acetylation status may interact to dictate the molecular mechanisms involved in this response. Parkinson disease, aquatic exercise, BDNF, epigenetic, grape juice.
本研究旨在调查一项与饮用葡萄汁（美洲葡萄）相关的水上体能训练计划对帕金森病患者的功能结局、脑源性神经营养因子（BDNF）以及外周血中整体组蛋白H4乙酰化水平的影响。
19名参与者被随机分为水上运动组（AQ，n = 9）和水上运动 + 葡萄汁组（AQ+GJ，n = 10），并进行为期4周的水上干预（每周两次，每次约60分钟）。在此期间，AQ+GJ组还每天饮用400毫升葡萄汁。在干预前后评估功能能力（六分钟步行测试，6MWT）、活动能力（起立行走测试，TUG）和跌倒风险（伯格平衡量表，BBS）。此外，采集血液进行生物标志物分析（如BDNF和整体组蛋白H4）。
水上运动计划使帕金森病患者的功能得到改善，特别是改善了他们的活动能力和功能能力。此外，干预后发现BDNF水平和组蛋白H4乙酰化水平有所提高。饮用葡萄汁并未增强这些效果，因为在所有分析变量中，AQ组和AQ+GJ组之间未发现任何显著差异。
本研究为帕金森病患者水上运动调节BDNF水平并伴有功能改善提供了重要见解，表明组蛋白乙酰化状态可能相互作用以决定参与这种反应的分子机制。帕金森病、水上运动、BDNF、表观遗传学、葡萄汁。
