Children's Hospital of Soochow University, Pediatric Research Institute of Soochow University, Suzhou, Jiangsu, 215123, China.
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
Biomaterials. 2020 Nov;258:120286. doi: 10.1016/j.biomaterials.2020.120286. Epub 2020 Aug 5.
Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or bacterial infection could further impede wound healing. Here, a type of ROS-scavenging hydrogel is developed by using polyvinyl alcohol (PVA) cross-linked by a ROS-responsive linker. The obtained hydrogel could act as an effective ROS-scavenging agent to promote the wound closure by decreasing the ROS level and up-regulating M2 phenotype macrophages around the wound. Importantly, such hydrogel formed in the wound could allow release of therapeutics, including mupirocin to kill bacteria, and granulocyte-macrophage colony-stimulating factor (GM-CSF) to accelerate the wound closure, in responsive to endogenous ROS existing in the wound microenvironment. Remarkably, our drug-loaded ROS-scavenging hydrogel could be employed to effectively treat various types of wounds including difficult-to-heal diabetic wounds with bacterial infection. Therefore, this work presents an effective strategy based on ROS-scavenging hydrogel for wound healing under various kinds of complications.
细菌感染一直是皮肤伤口的巨大威胁，特别是对难以愈合的糖尿病伤口。众所周知，伤口或细菌感染产生的活性氧（ROS）会进一步阻碍伤口愈合。在这里，通过使用对 ROS 有响应的连接子交联聚乙烯醇（PVA），开发了一种 ROS 清除水凝胶。所得到的水凝胶可以作为一种有效的 ROS 清除剂，通过降低 ROS 水平并在上皮周围上调 M2 表型巨噬细胞，从而促进伤口闭合。重要的是，这种在伤口中形成的水凝胶可以响应伤口微环境中存在的内源性 ROS，释放包括莫匹罗星杀死细菌和粒细胞-巨噬细胞集落刺激因子（GM-CSF）在内的治疗药物，以加速伤口闭合。值得注意的是，我们的载药 ROS 清除水凝胶可用于有效治疗各种类型的伤口，包括有细菌感染的难以愈合的糖尿病伤口。因此，这项工作提出了一种基于 ROS 清除水凝胶的有效策略，用于治疗各种并发症下的伤口愈合。
