Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y
Department of Otorhinolaryngology, Mie University School of Medicine, Japan.
Arch Otorhinolaryngol. 1988;244(6):355-9. doi: 10.1007/BF00497464.
We have evaluated the effect of serratiopeptidase (SER), a proteolytic enzyme, on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. SER was administered in a dose of 30 mg/day orally for 4 weeks. Nasal mucus was collected from the nasal cavities of each patient before (week 0) and 4 weeks after the start of the medication (week 4). The storage modulus (G') and the dynamic viscosity (eta') of each specimen of nasal mucus were determined by an oscillating sphere magnetic rheometer at frequencies of 0.5, 1, 5, 10 and 20 Hz at a constant temperature of 25 degrees C. The dynamic viscosity (eta') of the mucus at week 4 was significantly lower than that at week 0 (at frequencies of 5, 10 and 20 Hz). No significant differences were observed in the storage modulus (G') between the mucus at week 0 and week 4. SER reduced the viscosity but not the elasticity of the nasal mucus. These findings are discussed in relation to mucociliary clearance.
我们评估了蛋白水解酶沙雷氏菌肽酶（SER）对成年慢性鼻窦炎患者鼻腔黏液弹性和黏度的影响。SER以30毫克/天的剂量口服给药，持续4周。在用药前（第0周）和用药开始4周后（第4周）从每位患者的鼻腔收集鼻腔黏液。在25摄氏度恒温下，通过振荡球磁流变仪在0.5、1、5、10和20赫兹的频率下测定每个鼻腔黏液样本的储能模量（G'）和动态黏度（η'）。第4周时黏液的动态黏度（η'）显著低于第0周（在5、10和20赫兹频率下）。在第0周和第4周的黏液之间，未观察到储能模量（G'）有显著差异。SER降低了鼻腔黏液的黏度，但未降低其弹性。结合黏液纤毛清除功能对这些发现进行了讨论。
