Koshinsky H, Honour S, Khachatourians G
Department of Applied Microbiology and Food Service, University of Saskatchewan, Saskatoon, Canada.
Biochem Biophys Res Commun. 1988 Mar 15;151(2):809-14. doi: 10.1016/s0006-291x(88)80353-x.
T-2 toxin inhibits oxygen consumption of whole cells and purified mitochondria of Saccharomyces cerevisiae. Inhibition of mitochondrial respiration is not relieved by 2, 4-dinitrophenol, indicating that T-2 toxin inhibits mitochondrial function at the level of the electron transport chain. T-2 toxin inhibition of state 3 respiration (with succinate) is overcome by N, N, N', N'-tetramethyl-p-phenylenediamine, indicating inhibition of site II of the electron transport chain. T-2 toxin inhibits mitochondrial succinate dehydrogenase activity and increases mitochondrial NADH dehydrogenase activity.
