双磷酸盐给药时间对接受放射治疗的犬骨肉瘤细胞的影响。
Effect of timing of bisphosphonate administration on canine osteosarcoma cells undergoing radiation therapy.
机构信息
Department of Clinical Studies (Hoddinott, Oblak, Mutsaers) and Department of Pathobiology (Wood), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610-0126, USA (Boston).
出版信息
Can J Vet Res. 2020 Jul;84(3):225-229.
The effects of radiation therapy may be potentiated by combining radiation therapy with secondary therapies. Clinically, radiation therapy has been combined with bisphosphonates for treatment of canine appendicular osteosarcoma for years. The objective of this study was to determine if the timing of administration of bisphosphonates in relation to radiation therapy alters clonogenic survival or cell viability of canine osteosarcoma cells Canine osteosarcoma cells were treated before administration of radiation, concurrent with radiation, or after radiation. Reduction in clonogenic survival was identified when bisphosphonates were administered post-radiation compared with pre-radiation. No significant differences were identified for cell viability at any time points. Further investigation of the cellular effects of bisphosphonates on canine osteosarcoma cells is warranted. Consideration may be given to administering bisphosphonates 24 h after radiation to reduce replication of canine osteosarcoma cells and possibly prolong the analgesic effects of both treatments.
放射治疗与辅助治疗联合应用可能会增强放射治疗的效果。临床上，多年来放射治疗一直与双膦酸盐联合用于治疗犬四肢骨肉瘤。本研究的目的是确定双膦酸盐在放射治疗中的给药时间是否会改变克隆存活或犬骨肉瘤细胞的细胞活力。犬骨肉瘤细胞在给予放射治疗之前、同时给予放射治疗或之后进行治疗。与放射治疗前相比，放射治疗后给予双膦酸盐可降低克隆存活。在任何时间点，细胞活力均未显示出显著差异。有必要进一步研究双膦酸盐对犬骨肉瘤细胞的细胞作用。可以考虑在放射治疗后 24 小时内给予双膦酸盐，以减少犬骨肉瘤细胞的复制，并可能延长两种治疗方法的镇痛效果。
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