Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Healthc Eng. 2020 Jul 31;2020:8862256. doi: 10.1155/2020/8862256. eCollection 2020.
(1) To conduct a network meta-analysis of clinical drugs used for cardiogenic shock and (2) provide evidence for the selection of medication for the treatment of this condition.
PubMed, EMBASE, Cochrane library, China HowNet (CNKI), Wanfang database, and Weipu database were searched using keywords Dopamine, Dobutamine, Epinephrine, Adrenaline, Norepinephrine, Noradrenaline, Milrinone, Natriuretic peptide, Recombinant human brain natriuretic peptide, Levosimendan, Cardiac shock, and Cardiogenic shock. We select literature according to prespecified inclusion and exclusion criteria and record data such as drug type, mortality, and adverse reactions.
Twenty-eight of 1387 articles met inclusion criteria, comprising 1806 patients who suffered from cardiogenic shock. Dopamine, dobutamine, epinephrine, norepinephrine, milrinone, recombinant human brain natriuretic peptide, and levosimendan were all commonly used in the treatment of cardiogenic shock. Milrinone was most effective at reducing mortality and had the lowest incidence of adverse reactions.
This network meta-analysis demonstrated that milrinone was the most effective medication at reducing mortality and adverse events in patients suffering from cardiogenic shock.
（1）对用于心源性休克的临床药物进行网络荟萃分析，（2）为治疗这种疾病的药物选择提供证据。
使用关键词多巴胺、多巴酚丁胺、肾上腺素、去甲肾上腺素、去甲肾上腺素、米力农、利钠肽、重组人脑利钠肽、左西孟旦、心源性休克和心源性休克，在 PubMed、EMBASE、Cochrane 图书馆、中国知网（CNKI）、万方数据库和维普数据库中进行检索。我们根据预先设定的纳入和排除标准选择文献，并记录药物类型、死亡率和不良反应等数据。
在 1387 篇文章中，有 28 篇符合纳入标准，共纳入 1806 例心源性休克患者。多巴胺、多巴酚丁胺、肾上腺素、去甲肾上腺素、米力农、重组人脑利钠肽和左西孟旦均常用于治疗心源性休克。米力农在降低死亡率方面最有效，不良反应发生率最低。
这项网络荟萃分析表明，米力农是治疗心源性休克患者死亡率和不良事件最有效的药物。
