Katamba Cibangu, Chungu Theresa, Lusale Chisali
ART Department, Mkushi District Hospital, Mkushi, Zambia.
Administration Department, Mkushi District Hospital, Mkushi, Zambia.
F1000Res. 2019 Apr 26;8:562. doi: 10.12688/f1000research.17983.2. eCollection 2019.
Human Immunodeficiency Virus, syphilis and Hepatitis B Virus are major global public health problems, they are sexually transmitted infections with overlapping modes of transmission and affected populations. The aim of this study is to assess the seroprevalence of HIV 1, hepatitis B virus and syphilis coinfections among newly diagnosed HIV individuals aged 16 to 65 years, initiating on antiretroviral therapy, in Mkushi, Zambia. A total number of 126 sera were collected from HIV 1 infected patients attending Mkushi district hospital/ART clinic for antiretroviral therapy initiation. Hepatitis B surface antigen test and serologic test for syphilis were conducted between March and May 2018. Of the 126 participants (out of 131 enrollments), Hepatitis B surface antigen (HBsAg) was detected with a prevalence of 9.5% among newly diagnosed HIV infected patients, while that of syphilis was as high as 40.5% in this same population group. Three patients recorded HIV coinfections with both syphilis and hepatitis B virus (2.4%) at the same time. After analysis, the results indicate that there was no significant association between gender for both dependent variables: HIV/syphilis or HIV/hepatitis B virus coinfections (alpha significance level > 0.05). Those who had a history of syphilis infection in the past were more likely than those who had none to be HIV-syphilis coinfected (53.6% vs 34%, respectively; odd ratio [OR] 2.236; 95% confidence interval [CI] 1.045 - 4.782). The high prevalence rates for HIV, HBV, and syphilis coinfections strongly indicate the need for HBV and syphilis screening for HIV infected individuals. Furthermore, the high number of patients previously treated for syphilis who retest positive for syphilis in this study calls for use of the Venereal Disease Research Laboratory test to identify true syphilis infection (titers ≥ 1:8 dilutions, strongly suggestive).
人类免疫缺陷病毒、梅毒和乙型肝炎病毒是全球主要的公共卫生问题，它们是性传播感染，传播方式和受影响人群存在重叠。本研究的目的是评估在赞比亚姆库希，年龄在16至65岁、开始接受抗逆转录病毒治疗的新诊断艾滋病毒感染者中，HIV-1、乙型肝炎病毒和梅毒合并感染的血清流行率。从姆库希地区医院/抗逆转录病毒治疗诊所就诊的HIV-1感染患者中总共采集了126份血清，用于开始抗逆转录病毒治疗。2018年3月至5月期间进行了乙型肝炎表面抗原检测和梅毒血清学检测。在126名参与者（131名登记者中）中，新诊断的HIV感染患者中乙型肝炎表面抗原（HBsAg）的检出率为9.5%，而同一人群中梅毒的检出率高达40.5%。三名患者同时记录到HIV与梅毒和乙型肝炎病毒合并感染（2.4%）。经过分析，结果表明，两个因变量（HIV/梅毒或HIV/乙型肝炎病毒合并感染）的性别之间没有显著关联（α显著性水平>0.05）。过去有梅毒感染史的人比没有梅毒感染史的人更有可能合并感染HIV和梅毒（分别为53.6%和34%；比值比[OR]2.236；95%置信区间[CI]1.045 - 4.782）。HIV、HBV和梅毒合并感染的高流行率强烈表明，需要对HIV感染者进行HBV和梅毒筛查。此外，本研究中大量先前接受过梅毒治疗但梅毒检测再次呈阳性的患者，需要使用性病研究实验室检测来确定真正的梅毒感染（滴度≥1:8稀释，强烈提示）。
