rs924607与儿童急性淋巴细胞白血病中长春新碱诱导的神经病变：荟萃分析
rs924607 and vincristine-induced neuropathy in pediatric acute lymphocytic leukemia: meta-analysis.
作者信息
Zečkanović Aida, Jazbec Janez, Kavčič Marko
机构信息
Department for Pediatric Hematology & Oncology, University Children's Hospital of Ljubljana, University Medical Centre Ljubljana, Bohoričeva street 20, Ljubljana, Slovenia.
出版信息
Future Sci OA. 2020 May 27;6(7):FSO582. doi: 10.2144/fsoa-2020-0044.
AIM
We examined the utility of the rs924607 TT genotype of the () as a potential biomarker for predilection toward vincristine-induced peripheral neuropathy in children treated for acute lymphoblastic leukemia.
MATERIALS & METHODS: We conducted a random-effects meta-analysis of data from four studies comprising 817 patients. We tested for an association using a recessive model where a one-sided p-value < 0.05 was considered statistically significant.
RESULTS & CONCLUSION: We were unable to confirm the association between the rs924607 TT genotype and neurotoxicity (odds ratio: 1.99; p = 0.16; 95% CI: 0.76-5.25) in our global meta-analysis. Analysis of the continuation phase (following induction) studies showed significantly higher odds for neuropathy in rs924607 TT homozygotes (odds ratio: 2.28; p = 0.02; 95% CI: 1.16-6.87).
目的
我们研究了（）的rs924607 TT基因型作为接受急性淋巴细胞白血病治疗的儿童对长春新碱诱导的周围神经病变易感性潜在生物标志物的效用。
材料与方法
我们对四项研究中的817例患者数据进行了随机效应荟萃分析。我们使用隐性模型进行关联检验，单侧p值<0.05被认为具有统计学意义。
结果与结论
在我们的全球荟萃分析中，我们无法证实rs924607 TT基因型与神经毒性之间的关联（优势比：1.99；p = 0.16；95%置信区间：0.76 - 5.25）。对巩固期（诱导治疗后）研究的分析显示，rs924607 TT纯合子发生神经病变的几率显著更高（优势比：2.28；p = 0.02；95%置信区间：1.16 - 6.87）。
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