Huo Michael, Foley Heath, Pinkham Mark, Shanker Mihir, Bernard Anne, Jenkins Michael, Olson Sarah, Hall Bruce, Watkins Trevor, Jones Catherine, Foote Matthew
Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia.
Princess Alexandra Research Foundation, Woolloongabba, Brisbane, QLD, Australia.
J Radiosurg SBRT. 2020;7(1):11-17.
Hypofractionated stereotactic radiotherapy is a treatment option for large vestibular schwannomas supported by an increasing evidence. A single institution retrospective review of large (>3.5cc) vestibular schwannomas treated with hypofractionated stereotactic radiotherapy and single-session radiosurgery was conducted. Using serial follow up scans, a volumetric analysis of tumor volume change over time was performed. Vestibular schwannomas treated with hypofractionated stereotactic radiotherapy appeared to reduce in volume significantly faster than those treated with single-session radiosurgery. Cystic lesions reduced in volume faster than solid lesions. There was no significant difference in the rates of radiological and symptomatic oedema, nor subsequent dexamethasone requirement between the two treatment modalities.
大分割立体定向放射治疗是一种治疗大型前庭神经鞘瘤的选择，且证据日益增多。对接受大分割立体定向放射治疗和单次放射外科治疗的大型（>3.5cc）前庭神经鞘瘤进行了单机构回顾性研究。通过连续随访扫描，对肿瘤体积随时间的变化进行了容积分析。接受大分割立体定向放射治疗的前庭神经鞘瘤体积缩小明显快于接受单次放射外科治疗的肿瘤。囊性病变体积缩小比实性病变更快。两种治疗方式在放射性水肿和症状性水肿发生率以及随后地塞米松需求方面无显著差异。
