心脏手术后沙丁胺醇和硝普钠的血流动力学效应。
Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery.
作者信息
Poole-Wilson P A, Lewis G, Angerpointer T, Malcolm A D, Williams B T
出版信息
Br Heart J. 1977 Jul;39(7):721-5. doi: 10.1136/hrt.39.7.721.
Abstract
The haemodynamic effects of a continuous intravenous infusion of salbutamol (15 to 30 microgram/min) and nitroprusside (50 to 100 microgram/min) were compared in 9 patients after cardiac surgical operations. The mean falls in left atrial pressure and systemic vascular resistance were similar with the two drugs but salbutamol caused a greater increase in heart rate, maximum acceleration of aortic blood flow, and maximum rate of change of left ventricular power. Because these differences would cause greater myocardial oxygen consumption with salbutamol and because the infusion of salbutamol is less easily controlled, nitroprusside is the preferred drug after cardiac operations.
摘要
在9例心脏外科手术后的患者中，比较了持续静脉输注沙丁胺醇（15至30微克/分钟）和硝普钠（50至100微克/分钟）的血流动力学效应。两种药物使左心房压力和体循环血管阻力的平均降幅相似，但沙丁胺醇使心率、主动脉血流最大加速度和左心室功率最大变化率升高得更多。由于这些差异会导致使用沙丁胺醇时心肌氧耗增加，且输注沙丁胺醇较难控制，因此硝普钠是心脏手术后的首选药物。
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