Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Poland.
Department of Public Health, Medical University of Bialystok, Poland.
Biomed Res Int. 2020 Aug 4;2020:6403482. doi: 10.1155/2020/6403482. eCollection 2020.
Acute pancreatic injury can be related to both parenchymal (responsible for exocrine functions) and islet (mainly -cells, responsible for endocrine functions) damage. During embryonic development, both the salivary glands and the pancreas originate from the foregut, which explains many of the observed histological and functional similarities between these two organs. The relationship between several diseases of the pancreas and salivary glands, resulting from morphological and functional similarities, is well established. Sphingolipids constitute a class of biologically active molecules involved in numerous physiological and pathological processes, including acute pancreatitis (AP) and diabetes mellitus. However, the effect of AP on sphingolipid metabolism in the salivary glands remains uncertain. In the presented study, we examined the effect of AP and type 1 diabetes mellitus on sphingolipid metabolism in the salivary glands of rats. We demonstrated that acute pancreatic injury, related to both exocrine and endocrine functions, affects the metabolism of sphingolipids in the parotid, but not submandibular, salivary glands.
急性胰腺损伤可与实质（负责外分泌功能）和胰岛（主要是β细胞，负责内分泌功能）损伤有关。在胚胎发育过程中，唾液腺和胰腺均起源于前肠，这解释了这两个器官之间许多观察到的组织学和功能相似性。由于形态和功能相似，几种胰腺和唾液腺疾病之间存在关联。鞘脂类构成了一类生物活性分子，参与许多生理和病理过程，包括急性胰腺炎（AP）和糖尿病。然而，AP 对唾液腺鞘脂代谢的影响尚不确定。在本研究中，我们研究了 AP 和 1 型糖尿病对大鼠唾液腺鞘脂代谢的影响。我们表明，与外分泌和内分泌功能有关的急性胰腺损伤会影响腮腺，但不会影响颌下腺的鞘脂代谢。
