Staessen J, Fagard R, Van Hoof R, Amery A
Department of Pathophysiology, University of Leuven, Belgium.
Eur Heart J. 1988 Feb;9(2):215-22. doi: 10.1093/oxfordjournals.eurheartj.a062486.
Results on total and cause-specific mortality from various randomized intervention trials on antihypertensive drug treatment in elderly hypertensives are reviewed, compared and pooled. Mortality from all causes tended to decrease in all trials, but this decrease was not statistically significant in any of the trials separately, nor when all results were pooled. When the results of all the trials were combined, there was a significant overall decrease in cardiovascular mortality of 28%. This decrease in cardiovascular mortality was mainly related to a significant reduction in cerebrovascular mortality of 41%. Mortality from coronary heart disease also tended to decrease by 28%, but statistical significance was not reached.
本文对多项关于老年高血压患者降压药物治疗的随机干预试验中全因死亡率和特定病因死亡率的结果进行了回顾、比较和汇总。在所有试验中，全因死亡率均呈下降趋势，但在任何一项单独试验中，这种下降均无统计学意义，所有结果汇总后亦是如此。当所有试验结果合并时，心血管死亡率总体显著下降了28%。心血管死亡率的下降主要与脑血管死亡率显著降低41%有关。冠心病死亡率也有下降趋势，降幅为28%，但未达到统计学意义。
