二氟尼柳：对术后疼痛的疗效
Diflunisal: efficacy in postoperative pain.
作者信息
Van Winzum C, Rodda B
出版信息
Br J Clin Pharmacol. 1977 Feb;4 Suppl 1(Suppl 1):39S-43S. doi: 10.1111/j.1365-2125.1977.tb04513.x.
Abstract
- Seven hundred and forty patients complaining of pain after oral or orthopaedic surgery or episiotomy were studied in five single dose or short-term double-blind, controlled, randomized studies comparing efficacy and safety of diflunisal with that of acetylsalicylic acid, glafenin or placebo. 2. Diflunisal was found to be effective in relieving postoperative pain in 75-85% of patients. A twice day dosage schedule seems to be clinically adequate, 375 mg twice daily proving to be equally effective as glafenin 200 mg three times daily. No serious drug-related clinical or laboratory adverse experiences were encountered in any of the five studies.
摘要
- 在五项单剂量或短期双盲、对照、随机研究中，对740例口腔或矫形外科手术后或会阴切开术后疼痛的患者进行了研究，比较了双氯芬酸与乙酰水杨酸、格拉非宁或安慰剂的疗效和安全性。2. 发现双氯芬酸对75%-85%的患者缓解术后疼痛有效。每日两次的给药方案在临床上似乎足够，每日两次375毫克的疗效与每日三次200毫克的格拉非宁相当。在五项研究中的任何一项中均未遇到严重的药物相关临床或实验室不良事件。
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