MK-801在大鼠中具有苯环己哌啶样辨别刺激特性。
Phencyclidine-like discriminative stimulus properties of MK-801 in rats.
作者信息
Willetts J, Balster R L
机构信息
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
出版信息
Eur J Pharmacol. 1988 Jan 27;146(1):167-9. doi: 10.1016/0014-2999(88)90498-0.
The discriminative stimulus properties of the N-methyl-D-aspartate (NMDA) antagonist MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine) were investigated in rats trained to discriminate phencyclidine (PCP; 1.25 mg/kg i.p.) from saline on a standard two-lever fixed ratio 32 schedule of food reinforcement. MK-801 was generalized from PCP in a dose-dependent manner, with an ED50 of 0.10 mg/kg i.p. The ED50 for PCP was 0.7 mg/kg io.p. MK-801 is, therefore, a very potent PCP-like drug which may share cellular mechanisms and other effects with PCP, including the antagonism of NMDA.
在训练大鼠按照标准的双杠杆固定比率32食物强化程序区分苯环利定（PCP；腹腔注射1.25毫克/千克）和生理盐水的实验中，对N-甲基-D-天冬氨酸（NMDA）拮抗剂MK-801（(+)-5-甲基-10,11-二氢-5H-二苯并(a,d)环庚烯-5,10-亚胺）的辨别刺激特性进行了研究。MK-801以剂量依赖的方式从PCP泛化，腹腔注射的半数有效剂量（ED50）为0.10毫克/千克。PCP的ED50为腹腔注射0.7毫克/千克。因此，MK-801是一种非常强效的类PCP药物，可能与PCP共享细胞机制和其他效应，包括对NMDA的拮抗作用。
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