Equine Clinic Equivet, Gęsice 8, Domaniów, 55-216, Poland.
Department of Experimental Biology, Wroclaw University of Environmental and Life Sciences, Norwida 27B Street, A7 building, Wroclaw, 50-375, Poland.
Stem Cell Rev Rep. 2020 Dec;16(6):1328-1334. doi: 10.1007/s12015-020-10025-6.
Stem cell based therapy are now commonly applied in human and veterinary medical practice especially in orthopaedics. Mesenchymal stromal stem cells isolated from adipose tissue (ASC) are first choice option due to relatively non-invasive and safe procedure of tissue harvesting. However, ASC therapeutic potential strongly rely on patients general health condition, age and life-style. For that reason, to enhance therapeutic potential of cells, they are modified in vitro using different approaches. Previous studies have shown, that ASC treated with resveratrol, herein called SIRT+, are characterised by decreased senescence, increased proliferation rate and improved clinical outcome in autologous therapies. Herein, SIRT + cells in alginate hydrogel were applied to 5 years old warm breed mare was clinically evaluated due to the left hind lameness due to subchondral bone cyst. The therapeutic effect was assessed by the analysis of lameness score and radiological evaluation. This case report demonstrates the therapeutic potential of SIRT + cells in the treatment of orthopaedics disorders in horses as complete bone remodelling occurred after therapy and horse came back to training.
基于干细胞的疗法现在在人类和兽医医学实践中得到了广泛应用，尤其是在骨科领域。从脂肪组织中分离出来的间充质基质干细胞（ASC）是首选，因为这种组织采集方法相对非侵入性和安全。然而，ASC 的治疗潜力很大程度上取决于患者的一般健康状况、年龄和生活方式。因此，为了提高细胞的治疗潜力，它们在体外使用不同的方法进行修饰。先前的研究表明，用白藜芦醇处理的 ASC，即 SIRT+，表现出衰老减少、增殖率提高和在自体治疗中改善临床结果。在此，将 SIRT+细胞应用于 Alginate 水凝胶中，用于治疗 5 岁的温血母马，该马因软骨下骨囊肿导致左后肢跛行。通过跛行评分和放射学评估来评估治疗效果。该病例报告表明，SIRT+细胞在治疗马的骨科疾病方面具有治疗潜力，因为在治疗后出现了完全的骨重塑，马恢复了训练。
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