Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Molecular and Cellular Biology Program, University of Massachusetts Amherst, USA.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23466-23470. doi: 10.1002/anie.202008272. Epub 2020 Oct 23.
Nanocarrier-mediated drug delivery is a promising strategy to maximize the power of chemotherapy and minimize side effects. However, current approaches show insufficient drug-loading capacity and inefficient drug release, and require complex modification processes. Attempts to enhance one of these features often compromise other merits. We describe here a block copolymer assembly system that combines desirable characteristics. The design of self-immolative and crosslinkable hydrophobic moieties offer stable and high encapsulation. Redox-triggerable polymer self-immolation promotes drug release by switching the hydrophobic core into completely hydrophilic chains. The reactive amine handles, presented on their surface, allow "plug to direct" modification with targeting ligands. Functionalized nanoassemblies have been programmed to target specific subcellular compartments. The simplicity, versatility, and efficacy of the system open up possibilities for an all-in-one delivery system.
纳米载体介导的药物输送是一种有前途的策略，可以最大限度地提高化疗的效果，同时最小化副作用。然而，目前的方法显示出载药量不足和药物释放效率低下的问题，并且需要复杂的修饰过程。试图增强其中一个特性往往会损害其他优点。我们在这里描述了一种结合了所需特性的嵌段共聚物组装系统。自耗蚀和交联疏水性基团的设计提供了稳定和高的封装。氧化还原触发的聚合物自耗蚀通过将疏水性核心转变为完全亲水性链来促进药物释放。表面上呈现的反应性胺处理，允许“插件直接”用靶向配体进行修饰。功能化的纳米组装体被编程以靶向特定的亚细胞区室。该系统的简单性、多功能性和有效性为开发一种多功能的药物输送系统提供了可能。
