用于在亚细胞水平跟踪药物动态的先进成像技术。
Advanced imaging techniques for tracking drug dynamics at the subcellular level.
机构信息
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.
出版信息
Adv Drug Deliv Rev. 2023 Aug;199:114978. doi: 10.1016/j.addr.2023.114978. Epub 2023 Jun 28.
Abstract
Optical microscopes are an important imaging tool that have effectively advanced the development of modern biomedicine. In recent years, super-resolution microscopy (SRM) has become one of the most popular techniques in the life sciences, especially in the field of living cell imaging. SRM has been used to solve many problems in basic biological research and has great potential in clinical application. In particular, the use of SRM to study drug delivery and kinetics at the subcellular level enables researchers to better study drugs' mechanisms of action and to assess the efficacy of their targets in vivo. The purpose of this paper is to review the recent advances in SRM and to highlight some of its applications in assessing subcellular drug dynamics.
摘要
光学显微镜是一种重要的成像工具，它有效地推动了现代生物医学的发展。近年来，超分辨率显微镜（SRM）已成为生命科学领域中最受欢迎的技术之一，特别是在活细胞成像领域。SRM 已被用于解决基础生物学研究中的许多问题，并且在临床应用中具有很大的潜力。特别是，使用 SRM 来研究亚细胞水平的药物传递和动力学，使研究人员能够更好地研究药物的作用机制，并评估其在体内的靶标疗效。本文旨在综述 SRM 的最新进展，并强调其在评估亚细胞药物动力学方面的一些应用。
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