Clonal evolution and treatment outcomes in hematopoietic neoplasms arising in patients with germline RUNX1 mutations.

作者信息

Lachowiez Curtis, Bannon Sarah, Loghavi Sanam, Wang Feng, Kanagal-Shamanna Rashmi, Mehta Rohtesh, Daver Naval, Borthakur Gautam, Pemmaraju Naveen, Ravandi Farhad, Patel Keyur P, Garcia-Manero Guillermo, Takahashi Koichi, Kantarjian Hagop, Bhalla Kapil, DiNardo Courtney D

机构信息

Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

Clinical Cancer Genetics Program, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

出版信息

Am J Hematol. 2020 Nov;95(11):E313-E315. doi: 10.1002/ajh.25965. Epub 2020 Sep 5.

DOI:10.1002/ajh.25965

PMID:32804409

Abstract

摘要

相似文献

Clonal evolution and treatment outcomes in hematopoietic neoplasms arising in patients with germline RUNX1 mutations.

Am J Hematol. 2020 Nov;95(11):E313-E315. doi: 10.1002/ajh.25965. Epub 2020 Sep 5.

Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative analysis with somatic RUNX1 mutations in MDS/MPN overlap neoplasms.种系 RUNX1 家族性血小板疾病中的异常谱和克隆转化以及与 MDS/MPN 重叠肿瘤中体细胞 RUNX1 突变的基因组比较分析。

Leukemia. 2020 Sep;34(9):2519-2524. doi: 10.1038/s41375-020-0752-x. Epub 2020 Feb 14.

Bone Marrow Morphology Associated With Germline Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy.伴有骨髓恶性肿瘤的家族性血小板疾病患者中与种系突变相关的骨髓形态学

Pediatr Dev Pathol. 2019 Jul-Aug;22(4):315-328. doi: 10.1177/1093526618822108. Epub 2019 Jan 2.

Bone marrow pathologic abnormalities in familial platelet disorder with propensity for myeloid malignancy and germline RUNX1 mutation.家族性血小板疾病伴向髓性恶性肿瘤倾向和种系 RUNX1 突变的骨髓病理异常。

Haematologica. 2017 Oct;102(10):1661-1670. doi: 10.3324/haematol.2017.167726. Epub 2017 Jun 28.

Blood malignancies presenting with mutations at equivalent residues in RUNX1-2 suggest a common leukemogenic pathway.在RUNX1-2中相同残基处出现突变的血液恶性肿瘤提示存在一条共同的白血病发生途径。

Leuk Lymphoma. 2017 Aug;58(8):2002-2004. doi: 10.1080/10428194.2016.1274980. Epub 2017 Jan 16.

Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice.RUNX1-R188Q 种系突变可诱导小鼠炎症和血液系统恶性肿瘤易感性。

Blood Adv. 2023 Dec 12;7(23):7304-7318. doi: 10.1182/bloodadvances.2023010398.

Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes.144 例梅奥诊所遗传性易患综合征患者的血液系统恶性肿瘤谱、克隆进化和结局。

Am J Hematol. 2021 Nov 1;96(11):1450-1460. doi: 10.1002/ajh.26321. Epub 2021 Aug 27.

and germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia.以及一组在儿童急性淋巴细胞白血病治疗后发生继发性肿瘤的患者中的种系变异。

Haematologica. 2019 Sep;104(9):e402-e405. doi: 10.3324/haematol.2018.205849. Epub 2019 Jul 9.

Controversies about germline missense variants.关于种系错义变异的争议。

Leuk Lymphoma. 2020 Feb;61(2):497-499. doi: 10.1080/10428194.2019.1675882. Epub 2019 Oct 18.

Updates on germline predisposition in pediatric hematologic malignancies: What is the role of flow cytometry?儿科血液恶性肿瘤胚系易感性的研究进展：流式细胞术的作用是什么？

Cytometry B Clin Cytom. 2024 Sep;106(5):331-346. doi: 10.1002/cyto.b.22192. Epub 2024 Jun 28.

引用本文的文献

Disease characteristics and outcomes of acute myeloid leukemia in germline deficiency (Familial Platelet Disorder with associated Myeloid Malignancy).种系缺陷（伴有相关髓系恶性肿瘤的家族性血小板疾病）中急性髓系白血病的疾病特征及预后

Hemasphere. 2025 Jan 16;9(1):e70057. doi: 10.1002/hem3.70057. eCollection 2025 Jan.

Germline and somatic drivers in inherited hematologic malignancies.遗传性血液系统恶性肿瘤中的种系和体细胞驱动因素。

Front Oncol. 2023 Oct 13;13:1205855. doi: 10.3389/fonc.2023.1205855. eCollection 2023.

[Allogeneic hematopoietic stem cell transplantation for Familial platelet disorder with a propensity for acute myeloid malignancies with Runx1 germline mutations: a case report and literature review].[异基因造血干细胞移植治疗伴有Runx1种系突变的家族性血小板疾病伴急性髓系恶性肿瘤倾向：一例报告及文献综述]

Zhonghua Xue Ye Xue Za Zhi. 2022 Jun 14;43(6):517-520. doi: 10.3760/cma.j.issn.0253-2727.2022.06.013.

Beyond Pathogenic Germline Variants: The Spectrum of Somatic Alterations in RUNX1-Familial Platelet Disorder with Predisposition to Hematologic Malignancies.超越致病性胚系变异：易患血液系统恶性肿瘤的RUNX1-家族性血小板疾病中的体细胞改变谱

Cancers (Basel). 2022 Jul 14;14(14):3431. doi: 10.3390/cancers14143431.

The Emerging Role of Hematopathologists and Molecular Pathologists in Detection, Monitoring, and Management of Myeloid Neoplasms with Germline Predisposition.胚系易感性髓系肿瘤的检测、监测和管理中血液病理学家和分子病理学家的新作用

Curr Hematol Malig Rep. 2021 Aug;16(4):336-344. doi: 10.1007/s11899-021-00636-2. Epub 2021 May 24.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验