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在X/XSxr'雄性小鼠中不存在任何被T淋巴细胞识别的雄性特异性抗原。

Absence of any male-specific antigen recognized by T lymphocytes in X/XSxr' male mice.

作者信息

McLaren A, Hunt R, Simpson E

机构信息

MRC Mammalian Development Unit, London, U.K.

出版信息

Immunology. 1988 Mar;63(3):447-9.

Abstract

Previous work has established that whereas X/X mice carrying the sex-reversing chromosomal fragment Sxr are positive for the male-specific transplantation antigen, H-Y, X/X mice carrying the variant Sxr', although they too develop as phenotypic males, are H-Y negative. In this paper we show that X/XSxr' male mice do not express any male-specific antigen that can induce skin-graft rejection.

摘要

先前的研究已经证实,携带性别反转染色体片段Sxr的X/X小鼠对雄性特异性移植抗原H-Y呈阳性,而携带变异体Sxr'的X/X小鼠,尽管它们也发育为表型雄性,但却是H-Y阴性。在本文中,我们表明X/XSxr'雄性小鼠不表达任何可诱导皮肤移植排斥的雄性特异性抗原。

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Expression of H-Y antigen by female mice carrying Sxr.
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引用本文的文献

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Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome.
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6442-5. doi: 10.1073/pnas.85.17.6442.

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