对映选择性和区域选择性 NiH 催化的芳基碘化物与乙烯基芳烃的还原氢芳基化反应。
Enantio- and Regioselective NiH-Catalyzed Reductive Hydroarylation of Vinylarenes with Aryl Iodides.
机构信息
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, China.
出版信息
Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21530-21534. doi: 10.1002/anie.202010386. Epub 2020 Sep 21.
A highly enantio- and regioselective hydroarylation process of vinylarenes with aryl halides has been developed using a NiH catalyst and a new chiral bis imidazoline ligand. A broad range of structurally diverse, enantioenriched 1,1-diarylalkanes, a structure found in a number of biologically active molecules, have been obtained with excellent yields and enantioselectivities under extremely mild conditions.
一种高效的对映选择性和区域选择性的乙烯基芳烃与芳基卤化物的氢芳基化反应已经使用 NiH 催化剂和一种新的手性双咪唑啉配体开发出来。在极其温和的条件下，以优异的收率和对映选择性，获得了广泛的结构多样的、手性富集的 1,1-二芳基烷烃，该结构存在于许多生物活性分子中。
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