镍催化的1-芳基-1,3-丁二烯与芳基卤化物的区域选择性氢芳基化反应
Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides.
作者信息
Wang Chengdong, Guo Yingjie, Wang Xiaoming, Wang Zheng, Ding Kuiling
机构信息
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
出版信息
Chemistry. 2021 Nov 17;27(64):15903-15907. doi: 10.1002/chem.202102847. Epub 2021 Oct 1.
An efficient nickel-catalyzed regioselective hydroarylation of 1,3-dienes with aryl halides and a silane has been developed, affording a range of allylic arenes in good to excellent yields under mild conditions. This method exhibits broad substrate scope, and excellent functional group tolerance. Late-stage modification of complex architectures was demonstrated.
已开发出一种高效的镍催化 1,3 - 二烯与芳基卤化物和硅烷的区域选择性氢芳基化反应，在温和条件下能以良好至优异的产率得到一系列烯丙基芳烃。该方法具有广泛的底物范围和出色的官能团耐受性。还展示了对复杂结构的后期修饰。
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